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HomeProduct name listAURINTRICARBOXYLIC ACID

AURINTRICARBOXYLIC ACID

Synonym(s):ATA;Aurintricarboxylic Acid - CAS 4431-00-9 - Calbiochem

  • CAS NO.:4431-00-9
  • Empirical Formula: C22H14O9
  • Molecular Weight: 422.34
  • MDL number: MFCD00011663
  • EINECS: 224-628-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-18 17:01:59
AURINTRICARBOXYLIC ACID Structural

What is AURINTRICARBOXYLIC ACID?

Chemical properties

deep red coarse crystalline powder

The Uses of AURINTRICARBOXYLIC ACID

Aurintricarboxylic acid is employed as a powerful inhibitor of cellular processes, including apoptosis, that are dependent on the formation of protein-nucleic acid complexes. It binds to a FGF and reduces its angiogenic activity. Aurintricarboxylic Acid has been shown to inhibit apoptotic cell death in various cell types induced by a variety of factors. It Inhibits protein-nucleic acid interactions. It stimulates the tyrosine phosphorylation of MAP kinases.

The Uses of AURINTRICARBOXYLIC ACID

endonuclease inhibitor; apoptosis inhibitor, topoisomerase II inhibitor

What are the applications of Application

Aurintricarboxylic Acid is a cell-permeable apoptosis inhibitor

Definition

ChEBI: A member of the class of quinomethanes that is 3-methylidene-6-oxocyclohexa-1,4-diene-1-carboxylic acid in which the methylidene hydrogens are replaced by 4-carboxy-3-hydroxyphenyl groups. The trisodium salt is the biological stain 'chrome violet CG' while the triammonium salt is 'aluminon'.

Purification Methods

The acid is dissolved in aqueous NaOH, NaHSO3 solution is added until the colour is discharged and then the tricarboxylic acid is precipitated with HCl. [Heisig & Lauer Org Synth Coll Vol I 54 1941, Beilstein 10 IV 4161]. Do not extract the acid with hot water because it softens, forming a viscous mass. Make a solution in aqueous NH3. Aluminon is the NH4 salt.

Properties of AURINTRICARBOXYLIC ACID

Melting point: 300 °C(lit.)
Boiling point: 458.99°C (rough estimate)
Density  1.3860 (rough estimate)
refractive index  1.6230 (estimate)
storage temp.  +15C to +30C
solubility  1  M NH4OH: 10 mg/mL
pka 2.20±0.20(Predicted)
form  powder
color  dark red to brown
Water Solubility  Insoluble in water.
BRN  2228904
CAS DataBase Reference 4431-00-9(CAS DataBase Reference)
EPA Substance Registry System Benzoic acid, 5-[(3-carboxy-4-hydroxyphenyl)(3-carboxy-4-oxo-2,5-cyclohexadien-1-ylidene)methyl]-2-hydroxy- (4431-00-9)

Safety information for AURINTRICARBOXYLIC ACID

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405:Store locked up.

Computed Descriptors for AURINTRICARBOXYLIC ACID

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