APD668

CAS NO.：832714-46-2
Empirical Formula: C21H24FN5O5S
Molecular Weight: 477.51
MDL number: MFCD12032117
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 15:53:33

What is APD668?

The Uses of APD668

APD 668 is a potent agonist of GPR119, a glucose-dependant insulinotropic receptor expressed in pancreatic β-cells and intestinal L-cells.

References

[1]. semple g, ren a, fioravanti b, et al. discovery of fused bicyclic agonists of the orphan g-protein coupled receptor gpr119 with in vivo activity in rodent models of glucose control. bioorg med chem lett, 2011, 21(10):3134-41.
[2]. soga t, ohishi t, matsui t, et al. lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan g-protein-coupled receptor. biochem biophys res commun, 2005, 326(4):744-51.
[3]. overton ha, babbs aj, doel sm, et al. deorphanization of a g protein coupled receptor for oleoylethanolamide and its use in the discovery of small molecule hypophagic agents. cell metab, 2006, 3(3):167-75.

Properties of APD668

Boiling point:	611.6±55.0 °C(Predicted)
Density	1.47±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	insoluble in H2O; ≥17.4 mg/mL in DMSO; ≥2.61 mg/mL in EtOH with gentle warming and ultrasonic
form	solid
pka	2.13±0.30(Predicted)
color	White to off-white

Safety information for APD668

Computed Descriptors for APD668

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