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HomeProduct name listANTIBIOTIC UCN-02

ANTIBIOTIC UCN-02

  • CAS NO.:121569-61-7
  • Empirical Formula: C28H26N4O4
  • Molecular Weight: 482.53
  • MDL number: MFCD32174062
  • Update Date: 2024-07-02 08:55:08
ANTIBIOTIC UCN-02 Structural

What is ANTIBIOTIC UCN-02?

Description

UCN-02 is a derivative of staurosporine and a stereoisomer of UCN-01 first isolated from a high staurosporine-producing Streptomyces culture as a minor co-metabolite. UCN-02 inhibits protein kinase C with a slightly reduced potency than UCN-01 (IC50 = 62 and 4.1 nM, for UNC-02 and UCN-01, respectively) and is cytotoxic to the growth of HeLa S3 cells.

The Uses of ANTIBIOTIC UCN-02

UCN-02 is an indolocarbazole isolated from a high staurosporine-producing Streptomyces culture as a minor co-metabolite. Although less selective than its isomer UCN-01, UCN-02 exhibits comparable activity and probably acts by similar mechanisms.

The Uses of ANTIBIOTIC UCN-02

UCN-02 is an antibiotic and an indolocarbazole isolated from a high staurosporine-producing?Streptomyces?culture. Related analogs of staurosporine which is non-specific protein kinase inhibitor.

What are the applications of Application

UCN-02 is an antibiotic and an indolocarbazole isolated from a high staurosporine-producing Streptomyces culture

References

[1] takahashi, i. ,saitoh, y.,yoshida, m., et al. ucn-01 and ucn-02, new selective inhibitors of protein kinase c. ii. purification, physico-chemical properties, structural determination and biological activities. j.antibiot.(tokyo) 42(4), 571-576 (1989).
[2] newton a c. protein kinase c: structure, function, and regulation[j]. journal of biological chemistry, 1995, 270(48): 28495-28498.

Properties of ANTIBIOTIC UCN-02

Boiling point: 705.7±60.0 °C(Predicted)
Density  1.63±0.1 g/cm3(Predicted)
storage temp.  Store at -20°C
solubility  Soluble in DMSO
form  solution in ethanol.
pka 12.25±0.70(Predicted)
color  Colorless to light yellow

Safety information for ANTIBIOTIC UCN-02

Computed Descriptors for ANTIBIOTIC UCN-02

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