ANTI HUMAN TR-ALPHA

Synonym(s):Anti-α-Erythroblastic leukemia viral (v-erb-a) oncogene homolog;Anti-AR7;Anti-c-erbA-1;Anti-C-erbA-alpha;Anti-EAR7

Molecular Weight: 0
MDL number: MFCD02264166
Update Date: 2023-04-23 13:52:06

What is ANTI HUMAN TR-ALPHA?

The Uses of ANTI HUMAN TR-ALPHA

Anti-THRA antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org). Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit .

General Description

THRA (thyroid hormone receptor α) belongs to a family of nuclear receptors, which function as ligand-regulated transcription factors and are called thyroid hormone receptors (TRs). THRA is a predominant mammalian TR isoform. This receptor is highly expressed in central nervous system, myocardium, gastrointestinal tract and skeletal muscle.

Biochem/physiol Actions

Conserved lysine in the DNA-binding domain of this receptor functions as a sensor of transcriptional regulation. This lysine is mutated in hepatocellular carcinoma (HCC). Mutations in this protein result in resistance to thyroid hormone, which is alleviated by thyroxine treatment. Population with rs939348 TT polymorphism in this gene show weak relation to increased risk to Alzheimer′s disease. This receptor is also up-regulated in patients with breast cancer.

Properties of ANTI HUMAN TR-ALPHA

storage temp.	-20°C
form	buffered aqueous glycerol solution

Safety information for ANTI HUMAN TR-ALPHA

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for ANTI HUMAN TR-ALPHA

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