ANHYDROTETRACYCLINE HYDROCHLORIDE
Synonym(s):(4S,4aS,12aS)-4-(Dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-2-naphthacenecarboxamide monohydrochloride
- CAS NO.:13803-65-1
- Empirical Formula: C22H23ClN2O7
- Molecular Weight: 462.88
- MDL number: MFCD00151453
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is ANHYDROTETRACYCLINE HYDROCHLORIDE?
Description
The tetracycline repressor (TetR) is a transcriptional regulator which normally binds tightly to its palindromic tetO operator DNA, blocking gene expression. Tet causes the repressor to dissociate from the DNA, allowing transcription to occur. A novel reverse TetR (revTetR) requires tetracycline as a co-
Chemical properties
yellow to bright yellow powder
The Uses of ANHYDROTETRACYCLINE HYDROCHLORIDE
Anhydrotetracycline hydrochloride is a salt of a degradation product of tetracycline, formed by dehydration at the C6 position under acidic conditions to aromatise the B ring. Anhydrotetracycline is an important standard for monitoring tetracycline stability. Although the degradation is associated with a loss of antibiotic activity, anhydrotetracycline is considered biologically active and is thought responsible for aspects of tetracycline toxicity.
The Uses of ANHYDROTETRACYCLINE HYDROCHLORIDE
A Tetracycline derivative exhibiting no antibiotic activity, a useful effector of tetracycline-dependent gene expression in bacterial expression systems.
The Uses of ANHYDROTETRACYCLINE HYDROCHLORIDE
Anhydrotetracycline is a degradation product of tetracycline, formed by dehydration at the C6 position under acidic conditions to aromatise the B ring. Anhydrotetracycline is an important standard for monitoring tetracycline stability. Although the degradation is associated with a loss of antibiotic activity, anhydrotetracycline is considered biologically active and is thought responsible for aspects of tetracycline toxicity.
What are the applications of Application
Anhydrotetracycline Hydrochloride is A useful effector of tetracycline-dependent gene expression
Properties of ANHYDROTETRACYCLINE HYDROCHLORIDE
Melting point: | 223 °C |
RTECS | QI7860000 |
storage temp. | Refrigerator |
solubility | Soluble in ethanol, DMSO, or DMF |
form | Powder |
color | Yellow to bright yellow |
Sensitive | Moisture Sensitive |
BRN | 4228856 |
Stability: | Hygroscopic |
EPA Substance Registry System | 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-, hydrochloride (1:1), (4S,4aS,12aS)- (13803-65-1) |
Safety information for ANHYDROTETRACYCLINE HYDROCHLORIDE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 Health Hazard GHS08 |
GHS Hazard Statements |
H319:Serious eye damage/eye irritation H361:Reproductive toxicity |
Precautionary Statement Codes |
P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P308+P313:IF exposed or concerned: Get medical advice/attention. P403:Store in a well-ventilated place. |
Computed Descriptors for ANHYDROTETRACYCLINE HYDROCHLORIDE
Abamectin manufacturer
Varanous Labs Pvt Ltd
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