Amylmetacresol
Synonym(s):5-Methyl-2-pentylphenol;Amylmetacresol
- CAS NO.:1300-94-3
- Empirical Formula: C12H18O
- Molecular Weight: 178.27
- MDL number: MFCD00127710
- EINECS: 215-094-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-08 20:21:46
What is Amylmetacresol?
Absorption
Rapidly absorbed and eliminated .
Toxicity
Oral LD50: 1500 mg/kg (rat)
Adverse effects include hypersensitivity reactions, tongue soreness .
Occasionally, hypersensitivity reactions may occur, manifested by digestive problems such as nausea or dyspepsia. This is extremely rare .
In the case of overdose, management should be symptomatic. In cases of severe overdosage, gastric lavage may be warranted to empty the stomach contents. Saline laxatives and activated charcoal may be administered orally .
Chemical properties
Clear or almost clear liquid, or solid crystalline mass, colourless or slightly yellow when freshly prepared. The substance changes colour during storage by darkening and/or discolouration to dark yellow, brownish-yellow or pink.
The Uses of Amylmetacresol
Antiseptic. Amylmetacresol is an antiseptic available in Canada over-the-counter in a number of lozenges for the treatment of sore throat and minor mouth infections,. Amylmetacresol is often combined with dichlorobenzyl alcohol and menthol in the commonly used sore throat lozenges, known as Strepsils. The acute sore throat (pharyngitis) is one of the most common conditions for which children are seen in the primary care setting. Pharyngitis is normally caused by viruses and proves benign and self-limiting. Clinically proven, over-the-counter throat lozenges offer rapid and effective relief of acute sore throat symptoms, and are increasingly important in the management of this condition.
Background
Amylmetacresol is an antiseptic available in Canada over-the-counter in a number of lozenges for the treatment of sore throat and minor mouth infections , . Amylmetacresol is often combined with dichlorobenzyl alcohol and menthol in the commonly used sore throat lozenges, known as Strepsils .
The acute sore throat (pharyngitis) is one of the most common conditions for which children are seen in the primary care setting. Pharyngitis is normally caused by viruses and proves benign and self-limiting. Clinically proven, over-the-counter throat lozenges offer rapid and effective relief of acute sore throat symptoms, and are increasingly important in the management of this condition .
Indications
Sore throat, minor mouth and throat infections , , .
Definition
ChEBI: Amylmetacresol is a phenol having the structure of m-cresol substituted at the 6-position with an amyl group. It has a role as an antiseptic drug. It derives from a m-cresol.
Pharmacokinetics
The mixture of amylmetacresol throat lozenge medications markedly reduces the infectivity of certain infectious viruses in the throat and in cough droplets, thus reducing opportunities for person-to-person transmission . In addition, it relieves symptoms of sore throat/irritation of the throat , .
Amylmetacresol is thought to inhibit the inflammatory and pain mediators that are involved in the inflammation of the mouth and throat mucous membranes, as well as the sore throat .
Metabolism
Not Available
Mode of action
The mechanism of virucidal action is not fully elucidated, however it is suggested that denaturation of external protein spikes, a pH-induced rearrangement of the tertiary structure of attachment proteins, or a selective effect on viral lipid membranes/protein–lipid interaction is responsible for this action. Amylmetacresol is an antibacterial and antiviral agent, and blocks voltage-gated Na channels in a local anesthetic-like manner.
Properties of Amylmetacresol
Melting point: | 24°C |
Boiling point: | 139°C/15mmHg(lit.) |
Density | 0.9414 (estimate) |
refractive index | 1.5120 to 1.5160 |
storage temp. | Inert atmosphere,Room Temperature |
solubility | Practically insoluble in water, very soluble in acetone and in ethanol (96 per cent). |
form | neat |
pka | 10.55±0.35(Predicted) |
form | Liquid |
color | Yellow to Dark Orange |
EPA Substance Registry System | Phenol, 5-methyl-2-pentyl- (1300-94-3) |
Safety information for Amylmetacresol
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Computed Descriptors for Amylmetacresol
Abamectin manufacturer
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