AMD 3465 (Hexahydrobromide)

Synonym(s):AMD 3465;GENZ-644494;N-[[4-(1,4,8,11-Tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-2-pyridinemethanamine hexahydrobromide

CAS NO.：185991-07-5
Empirical Formula: C24H39BrN6
Molecular Weight: 491.52
MDL number: MFCD20926342
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-14 14:09:35

AMD 3465 (*Hexahydrobromide*) Structural

What is AMD 3465 (Hexahydrobromide)?

The Uses of AMD 3465 (Hexahydrobromide)

AMD 3465 is a CXCR4 antagonist and in combination with monoclonal antibody, was shown to be potentially effective in reducing tumor growth and increasing survival in patient with B cell lymphoma

What are the applications of Application

AMD 3465 hexahydrobromide is a selective and potent CXCR4 antagonist

Biochem/physiol Actions

AMD3465 is also termed as{N-[1,4,8,11-tetraazacyclotetradecanyl-1,4-phenylenebis(methylene)]-2-(aminomethyl)pyridine}. It controls oncogenic signaling and invasiveness in vitro. It inhibits breast cancer growth and metastasis in vivo. As a chemokine receptor 4 (CXCR4) antagonist, AMD3465 is ten times more efficient than bicyclam AMD3100.

storage

Store at -20°C

Properties of AMD 3465 (Hexahydrobromide)

Melting point:	>200°C (dec.)
storage temp.	-20°C
solubility	DMSO (Slightly), Methanol (Very Slightly), Water (Slightly)
form	powder
color	white to light brown

Safety information for AMD 3465 (Hexahydrobromide)

Computed Descriptors for AMD 3465 (Hexahydrobromide)

New Products

4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile Diclofenac Potassium Ornidazole IP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Aceclofenac IP/BP/EP Nimesulide BP SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION SODIUM METHYL PARABEN Methylcobalamin (vitamin B12) SODIUM VALPROATE Racecadotril XANTHAN GUM

AMD 3465 (*Hexahydrobromide*)

Synonym(s):AMD 3465;GENZ-644494;N-[[4-(1,4,8,11-Tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-2-pyridinemethanamine hexahydrobromide

What is AMD 3465 (*Hexahydrobromide*)?

The Uses of AMD 3465 (*Hexahydrobromide*)