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HomeProduct name listALPHA-HYDROXY-GAMMA-BUTYROLACTONE

ALPHA-HYDROXY-GAMMA-BUTYROLACTONE

Synonym(s):4,5-Dihydro-3-hydroxy-2(3H)-furanone

ALPHA-HYDROXY-GAMMA-BUTYROLACTONE Structural

What is ALPHA-HYDROXY-GAMMA-BUTYROLACTONE?

Chemical properties

clear colorless to yellow viscous liquid

The Uses of ALPHA-HYDROXY-GAMMA-BUTYROLACTONE

α-Hydroxy-γ-butyrolactone may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. 1 It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.

The Uses of ALPHA-HYDROXY-GAMMA-BUTYROLACTONE

α-Hydroxy-γ-butyrolactone may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.

What are the applications of Application

α-Hydroxy-γ-butyrolactone is used to initiate the synthesis of series of seco-pseudonucleoside synthons via aminolysis

General Description

α-Hydroxy-γ-butyrolactone is a 5-membered cyclic ester. It was obtained via tin-conversion of biomass-derived 1,3-dihydroxyacetone (DHA) and formaldehyde.

Purification Methods

It has been purified by repeated fractionation and forms a colourless liquid. It has to be distilled at high vacuum; otherwise it will dehydrate. The acetox

Properties of ALPHA-HYDROXY-GAMMA-BUTYROLACTONE

Boiling point: 133 °C/10 mmHg (lit.)
Density  1.309 g/mL at 25 °C (lit.)
refractive index  n20/D 1.468(lit.)
Flash point: >230 °F
storage temp.  Inert atmosphere,Room Temperature
solubility  Chloroform (Sparingly), Methanol (Slightly)
form  Viscous Liquid
pka 13.07±0.20(Predicted)
color  Clear colorless to yellow
BRN  80587
CAS DataBase Reference 19444-84-9(CAS DataBase Reference)

Safety information for ALPHA-HYDROXY-GAMMA-BUTYROLACTONE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for ALPHA-HYDROXY-GAMMA-BUTYROLACTONE

InChIKey FWIBCWKHNZBDLS-UHFFFAOYSA-N

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