ALPHA-HELICAL CRF (9-41)
Synonym(s):α-Helical corticotropin releasing factor fragment (9-41);α-Helical CRF (9-41)
- CAS NO.：99658-03-4
- Empirical Formula: C22H25IN2O6
- Molecular Weight: 540.34817
- MDL number: MFCD00081543
- Update Date: 2023-04-23 13:52:06
What is ALPHA-HELICAL CRF (9-41)?
Biochem/physiol Actions
The corticotropin releasing factor (CRF) antagonist α-helical CRF [9-41] exhibits 10-fold higher affinity for rat CRF2α receptors over human CRF2α receptors. It has been used to elucidate the role of CRF in various physiological systems. In colonic epithelium, it abolishes CRF-induced changes in ion secretion, and significantly inhibits CRF-stimulated conductance. It antagonizes the CRF-induced proinflammatory degranulation of perivascular mast cells that are activated in response to acute psychological stress and CRF secretion.
Properties of ALPHA-HELICAL CRF (9-41)
| storage temp. | −20°C |
| form | powder |
| color | white |
Safety information for ALPHA-HELICAL CRF (9-41)
Computed Descriptors for ALPHA-HELICAL CRF (9-41)
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