Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name list3-chloro-4-(pyridin-2-ylmethoxy)aniline

3-chloro-4-(pyridin-2-ylmethoxy)aniline

  • CAS NO.:524955-09-7
  • Empirical Formula: C12H11ClN2O
  • Molecular Weight: 234.68
  • MDL number: MFCD08699389
  • EINECS: 1592732-453-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-04-10 08:42:08
3-chloro-4-(pyridin-2-ylmethoxy)aniline Structural

What is 3-chloro-4-(pyridin-2-ylmethoxy)aniline?

The Uses of 3-chloro-4-(pyridin-2-ylmethoxy)aniline

3-Chloro-4-(2-pyridylmethoxy)aniline was used for preparation of disubstituted (arylamino)quinolinecarbonitriles as orally active irreversible inhibitors of human epidermal growth factor receptor-2 kinase activity and antitumor agents.

Synthesis

3-chloro-4-(pyridin-2-ylmethoxy)aniline is synthesised using 2-((2-Chloro-4-nitrophenoxy)methyl)pyridine as a raw material by chemical reaction. The specific synthesis steps are as follows:
The 2-((2-chloro-4-nitrophenoxy)methyl)pyridine (3.9 g, 15 mmol), zinc powder (5.8 g, 88 mmol) and ammonium chloride (2.4 g, 44 mmol) were added into a mixed solution of ethanol (60 mL) and H2O (10 mL). The mixture was stirred at 60° C. overnight. Then the reaction mixture was poured into 200 mL of H2O, extracted with ethyl acetate. The organic phase was separated, washed with saturated brine and dried. The solvent was removed in vacuo, and the compound shown in the title (3.4 g, 98percent) was obtained. 1H NMR (CDCl3): δ 8.57 (1H, d, J=4.8 Hz), 7.75-7.70 (1H, m), 7.65-7.63 (1H, m), 7.23-7.20 (1H, m), 6.81 (1H, d, J=9.2 Hz), 6.77 (1H, d, J=2.8 Hz), 5.18 (2H, s), 3.48 (2H, br).
3-chloro-4-(pyridin-2-ylmethoxy)aniline synthesis

Properties of 3-chloro-4-(pyridin-2-ylmethoxy)aniline

Melting point: 91.0 to 95.0 °C
Boiling point: 402.5±35.0 °C(Predicted)
Density  1.292±0.06 g/cm3(Predicted)
storage temp.  Keep in dark place,Inert atmosphere,Room temperature
form  powder to crystal
pka 3.88±0.10(Predicted)
color  White to Light yellow to Light orange

Safety information for 3-chloro-4-(pyridin-2-ylmethoxy)aniline

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 3-chloro-4-(pyridin-2-ylmethoxy)aniline

Related products of tetrahydrofuran

You may like

  • 524955-09-7 [3-Chloro-4-(pyridin-2-ylmethoxy)phenyl]amine 98%
    524955-09-7 [3-Chloro-4-(pyridin-2-ylmethoxy)phenyl]amine 98%
    524955-09-7
    View Details
  • 524955-09-7 99%
    524955-09-7 99%
    524955-09-7
    View Details
  • 3-Chloro-4-(2-pyridylmethoxy)aniline CAS 524955-09-7
    3-Chloro-4-(2-pyridylmethoxy)aniline CAS 524955-09-7
    524955-09-7
    View Details
  • 1823368-42-8 98%
    1823368-42-8 98%
    1823368-42-8
    View Details
  • 2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%
    2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%
    1307449-08-6
    View Details
  • Ethyl 3-(furan-2-yl)-3-hydroxypropanoate 25408-95-1 98%
    Ethyl 3-(furan-2-yl)-3-hydroxypropanoate 25408-95-1 98%
    25408-95-1
    View Details
  • 2-Chloro-5-fluoro-1-methoxy-3-methylbenzene 98%
    2-Chloro-5-fluoro-1-methoxy-3-methylbenzene 98%
    1805639-70-6
    View Details
  • Lithium Clavulanate
    Lithium Clavulanate
    61177-44-4
    View Details
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.