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HomeProduct name listAdrenocorticotropic hormone

Adrenocorticotropic hormone

Synonym(s):Adrenocorticotropic Hormone Fragment 1-39;Corticotropin A

  • CAS NO.:9061-27-2
  • Empirical Formula: C210H314N56O57S
  • Molecular Weight: 4567.14616
  • MDL number: MFCD00167432
  • EINECS: 232-946-7
  • Update Date: 2024-01-03 18:42:19
Adrenocorticotropic hormone  Structural

What is Adrenocorticotropic hormone ?

Indications

Adrenocorticotropic hormone (ACTH), or corticotropin, a peptide of 39 amino acids, is first synthesized as a larger precursor from which ACTH is derived by proteolytic cleavage. ACTH stimulates production of glucocorticoids from the adrenal cortex. Release of ACTH depends on diurnal rhythms with serum levels highest in the early morning. Secretion of this peptide also increases under stress. It is easier and less expensive to treat patients having adrenocortical insufficiency with glucocorticoid replacement therapy than it is to use ACTH. Therefore, use of ACTH (Acthar) is restricted to diagnosis; a shorter 24–amino acid analogue (Cosyntropin) is also used. Intravenous administration of ACTH should result in peak plasma levels of glucocorticoids within 30 to 60 minutes if the adrenal gland is functional. Prolonged administration of ACTH in a repository form, however, may be necessary to stimulate steroid production, because ACTH has long-term trophic effects on adrenal cells in addition to the rapid stimulation of steroid production. If the cause of steroid deficiency is at the level of the pituitary gland, ACTH should eventually stimulate steroid production.

Biological Functions

The main function of Adrenocorticotropic hormone (ACTH) is to regulate the glucocorticoid (steroid) hormone cortisol. Cortisol is released by the adrenal gland. It regulates blood pressure, blood sugar, the immune system, and the response to stress. This test can help find the causes of certain hormone problems

Health Hazard

Adrenocorticotropic Hormone (ACTH;Adrenocorticotropin; corticotropic hormone): (1)Maintenance of adrenal cortex;(2)Promotes secretion of steroids, oxidative phosphorylation in adrenal cortex;(3)Mobilizes and increases oxidation of free fatty acid in adipose tissue;(4)Increases gluconeogenesis in liver; increases cyclic adenosine monophosphate (AMP) in adrenal cortex;Decreases urea formation in liver.

Biochem/physiol Actions

Stimulates synthesis and secretion of glucocorticoids by adrenal cortex.

Producing and consuming organs

The anterior pituitary produces ACTH. It is considered a tropic hormone. Tropic hormones indirectly affect target cells by first stimulating other endocrine glands. Corticotropin-releasing hormone (CRH) is released from the hypothalamus, which stimulates the anterior pituitary to release adrenocorticotropic hormone (ACTH). ACTH then acts on its target organ, the adrenal cortex.

Properties of Adrenocorticotropic hormone

storage temp.  −20°C
form  powder

Safety information for Adrenocorticotropic hormone

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
ghs
Health Hazard
GHS08
GHS Hazard Statements H302:Acute toxicity,oral
H312:Acute toxicity,dermal
H332:Acute toxicity,inhalation
H351:Carcinogenicity
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for Adrenocorticotropic hormone

InChIKey XFBDTKGDXZDJAN-WODOTNDISA-N

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