Acotiamide Hydrochloride
- CAS NO.:185104-11-4
- Empirical Formula: C21H31ClN4O5S
- Molecular Weight: 487.01
- MDL number: MFCD23103502
- EINECS: 203-105-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 13:36:13
What is Acotiamide Hydrochloride?
Description
Acotiamide Hydrochloride (YM-443, Z-338) is the hydrochloride salt form of acotiamide, a prokinetic agent with gastrointestinal (GI) motility-enhancing activity. It is a new orally active selective acetylcholinesterase inhibitor. Although the exact mechanism by which acotiamide exerts its effect has yet to be fully elucidated, this agent appears to inhibit acetylcholinesterase (AchE), an enzyme responsible for the breakdown of acetylcholine (Ach). Increased Ach concentrations lead to an improvement of gastric emptying and GI motility and eventually to a reduction of dyspepsia symptoms.
The Uses of Acotiamide Hydrochloride
Acotiamide Hydrochloride is an acetylcholinesterase inhibitor which has been shown to stimulate gastric motility and improve gastric motility dysfunction in rats (1,2). Acotiamide Hydrochloride has also been shown to improve meal-related symptoms of functional dyspepsia.
Biological Activity
Acotiamide hydrochloride is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with an IC50 of 1.79 μM. Acotiamide hydrochloride can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide hydrochloride has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory.
Properties of Acotiamide Hydrochloride
storage temp. | Sealed in dry,Store in freezer, under -20°C |
Safety information for Acotiamide Hydrochloride
Computed Descriptors for Acotiamide Hydrochloride
Abamectin manufacturer
Vijaya Pharma And Life Science
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