ACK1-B19
- CAS NO.：1234480-46-6
- Empirical Formula: C24H27N7O2
- Molecular Weight: 445.52
- MDL number: MFCD30742941
- Update Date: 2024-07-02 08:55:41
What is ACK1-B19?
Description
XMD8-87 is an inhibitor of tyrosine kinase non-receptor 2 (TNK2) with an IC50 value of 1.9 μM in HEK293T cells expressing human TNK2. It is selective for TNK2 over a panel of approximately 100 kinases with >90 and <50% inhibition for TNK2 and all other kinases tested, respectively. XMD8-87 inhibits growth of Ba/F3 cells expressing constitutively active mutant TNK2s (IC50s = 0.1-77 nM) commonly found in leukemias but has no effect on cells expressing wild-type TNK2 (IC50 = >1 μM).
The Uses of ACK1-B19
XMD8-87 is used in the studies of benzopyrimidodiazepinones as most selective and potent ERK5 inhibitor.
Properties of ACK1-B19
| Density | 1.283±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: 1 mg/ml; DMSO: 1 mg/ml; Ethanol: 1 mg/ml |
| form | A crystalline solid |
| pka | 10.18±0.20(Predicted) |
| color | White to yellow |
Safety information for ACK1-B19
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for ACK1-B19
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