(ACETYLMETHYLENE)TRIPHENYLPHOSPHORANE
Synonym(s):(2-Oxopropylidene)triphenylphosphorane;Acetylmethylene-triphenylphosphorane;Methyl (triphenylphosphoranylidene)methyl ketone;NSC 407394
- CAS NO.：1439-36-7
- Empirical Formula: C21H19OP
- Molecular Weight: 318.35
- MDL number: MFCD00008774
- EINECS: 215-878-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-19 10:45:16
What is (ACETYLMETHYLENE)TRIPHENYLPHOSPHORANE?
Chemical properties
white to light beige crystalline powder
The Uses of (ACETYLMETHYLENE)TRIPHENYLPHOSPHORANE
(Acetylmethylene)triphenylphosphorane is used as a Wittig reagent in synthetic chemistry, especially for the synthesis of functionalized pyrrolidines and cyclobutanones. It plays as a vital role in asymmetric allylboration for enantioselective synthesis of (+)-awajanomycin.It is also employed as a reactant in the preparation of 1,2-dioxanes with antitrypanosomal activity. Further, it is used in the preparation of amphibian pyrrolizidine alkaloids through allylic aminations and silicon-containing acyclic dienone musk odorants. In addition to this, it is involved in Domino Suzuki/Heck coupling reactions to prepare fluorenylidenes.
Properties of (ACETYLMETHYLENE)TRIPHENYLPHOSPHORANE
| Melting point: | 203-205 °C (lit.) |
| Boiling point: | 478.5±28.0 °C(Predicted) |
| Density | 1.14 |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Soluble in chloroform. Slightly soluble in methanol. |
| form | Powder |
| color | White to off-white |
| Sensitive | Air Sensitive |
| BRN | 750077 |
| Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. |
| CAS DataBase Reference | 1439-36-7(CAS DataBase Reference) |
Safety information for (ACETYLMETHYLENE)TRIPHENYLPHOSPHORANE
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (ACETYLMETHYLENE)TRIPHENYLPHOSPHORANE
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