acetyl Methanesulfonate
- CAS NO.：5539-53-7
- Empirical Formula: C3H6O4S
- Molecular Weight: 138.14
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is acetyl Methanesulfonate?
The Uses of acetyl Methanesulfonate
Acetyl Methanesulfonate, is an impurity of Busulfan (B689900), an alkylating agent with antileukemic activity. Antineoplastic.
Purification Methods
The main impurity is methanesulfonic acid. Reflux it with redistilled acetyl chloride for 6-10hours, i.e. until no further HCl is absorbed in a trap, and exclude moisture. Distil off excess of AcCl and carefully distil it below 0.001mm with the bath temperature below 120o to give the anhydride as a pale yellow oil which solidifies below 0o. Below ~130o it gives the disulfonic anhydride, and above ~130o polymers are formed, and it is used for cleaving ethers [Preparation, IR, NMR: Karger & Mazur J Org Chem 36 528, 532 1971]. [Beilstein 2 H 166, 2 III 349.]
Properties of acetyl Methanesulfonate
| Boiling point: | 56 °C(Press: 0.01 Torr) |
| Density | 1.346±0.06 g/cm3(Predicted) |
| storage temp. | Hygroscopic, Refrigerator, under inert atmosphere |
| solubility | Chloroform (Sparingly) |
| form | Oil |
| color | Yellow |
| Stability: | Extremely Moisture Sensitive |
Safety information for acetyl Methanesulfonate
Computed Descriptors for acetyl Methanesulfonate
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