ACA

CAS NO.：99196-74-4
Empirical Formula: C21H23NO3
Molecular Weight: 337.41
MDL number: MFCD01321668
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-04 17:34:44

What is ACA?

The Uses of ACA

N-(p-Amylcinnamoyl)anthranilic acid has been used as a transient receptor potential cation channel subfamily M member 2 (TRPM2) inhibitor, in studying its role in regulating the production of reactive oxygen species (ROS).

Definition

ChEBI: N-(p-amylcinnamoyl)anthranilic acid is an amidobenzoic acid that is anthranilic acid in which one of the anilino hydrogens is replaced by a 4-pentylcinnamoyl group. It is a transient receptor potential (TRP) channel blocker and phospholipase A2 (PLA2) inhibitor. It has a role as an EC 3.1.1.4 (phospholipase A2) inhibitor and a TRP channel blocker. It is an amidobenzoic acid, a member of cinnamamides and a secondary carboxamide.

General Description

N-(p-Amylcinnamoyl)anthranilic acid (ACA) functions as a broad spectrum phospholipase A2 inhibitor and blocks transient receptor potential (TRP) channels. It inhibits calcium activated chloride current in cardiac ventricular myocytes. ACA regulates various ion channels.

Biochem/physiol Actions

Broad spectrum phospholipase A2 (PLA2) inhibitor and TRP channel blocker.

Properties of ACA

Boiling point:	563.1±50.0 °C(Predicted)
Density	1.178±0.06 g/cm3(Predicted)
storage temp.	room temp
solubility	DMSO: ≥20mg/mL
pka	3.46±0.36(Predicted)
form	powder
color	white to off-white

Safety information for ACA

Signal word	Warning
Pictogram(s)	Environment GHS09
GHS Hazard Statements	H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P273:Avoid release to the environment. P501:Dispose of contents/container to..…