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HomeProduct name listAC2-12

AC2-12

Synonym(s):Annexin A1;Annexin I;ANX1;ANXA1;LPC1

AC2-12 Structural

What is AC2-12?

Enzyme inhibitor

This annexin/lipocortin-1 peptidomimetic (FW = 1351.58 g/mol; Sequence: Acetyl-AMVSEFLKQAW; CAS 256447-08-2; Soluble to 1 mg/mL in 20% (vol/vol) acetonitrile-H2O) markedly reduces the degree of neutrophil adhesion and emigration across mouse mesenteric postcapillary venules, when administered at 13 mg/kg (s.c.), but does not modify cell rolling, when assessed directly by intravital microscopy. Ac2-12 also promotes neutrophil detachment from mesenteric endothelium after activation by intraperitoneal injection of 1 mg zymosan in mice (i.e., zymosan peritonitis). Ac2-12 phenocopies the effects observed in FormylatedPeptide Receptor (FPR) knock-out mice.

Properties of AC2-12

storage temp.  -20°C
form  Solid
color  White to off-white
Water Solubility  Soluble to 1 mg/ml in 20% acetonitrile / Water

Safety information for AC2-12

Computed Descriptors for AC2-12

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