(9-phenyl-9H-carbazol-2-yl)boronic acid

CAS NO.：1001911-63-2
Empirical Formula: C18H14BNO2
Molecular Weight: 287.12
MDL number: MFCD22207050
SAFETY DATA SHEET (SDS)
Update Date: 2024-07-19 18:29:52

What is (9-phenyl-9H-carbazol-2-yl)boronic acid?

The Uses of (9-phenyl-9H-carbazol-2-yl)boronic acid

(9-phenyl-9H-carbazol-2-yl)boronic acid can be used as an intermediate in organic synthesis, mainly used in laboratory research and development and in the process of chemical and pharmaceutical synthesis.

Synthesis

Synthesis_1001911-63-2_2
Sub 1-3-1 (6.4g, 20mmol) was dissolved in anhydrous Ether, lowering the temperature of the reaction to -78??C, n-BuLi (2.5M in hexane) (1.4g, 22mmol) was added dropwise slowly, and after, the reaction It was stirred for 30 minutes. After lowering the temperature of the reaction back to -78??C dropwise Triisopropyl borate (5.6g, 30mmol). Stirring at room temperature, diluted with water and it binds the 2N HCl. After completion of reaction, ethyl acetate and water, dried over MgSO4 and the organic layer was extracted and recrystallized silicagel column and the resulting organic material and then concentrated to a Sub 1-4-1 4.5g (yield: 78%) was obtained.

Properties of (9-phenyl-9H-carbazol-2-yl)boronic acid

Boiling point:	466.0±51.0 °C(Predicted)
Density	1.20±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	very slightly in Tetrahydrofuran
form	powder to crystal
pka	8.91±0.30(Predicted)
color	White to Almost white

Safety information for (9-phenyl-9H-carbazol-2-yl)boronic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention.