8-Chloro-3-iodoimidazo[1,2-a]pyrazine
- CAS NO.:1049677-32-8
- Empirical Formula: C6H3ClIN3
- Molecular Weight: 279.47
- MDL number: MFCD11053343
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-10-16 11:32:06
What is 8-Chloro-3-iodoimidazo[1,2-a]pyrazine?
Chemical properties
off-white solid
Biological Activity
8-Chloro-3-iodoimidazo[1,2-a]pyrazine has demonstrated broad-spectrum antibacterial activity at low concentration levels against both gram-positive and gram-negative bacteria. Its antimicrobial potency can be increased by structural modifications.
Synthesis
8-chloroimidazo[1,2-a]pyrazine (5.2 g, 33.9 mmol) and N-iodo-succinimide (NIS) (8 g, 35.6 mmol) were combined with DMF (34 ml). The reaction mixture was stirred at RT for 48 h. After that, the water was added to the suspension, and the solid was filtered, washed with water and MeOH, and dried under HV to afford 8-Chloro-3-iodoimidazo[1,2-a]pyrazine (7.17 g, 25.6 mmol, 75.8% yield).
Properties of 8-Chloro-3-iodoimidazo[1,2-a]pyrazine
Density | 2.34 |
Safety information for 8-Chloro-3-iodoimidazo[1,2-a]pyrazine
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 8-Chloro-3-iodoimidazo[1,2-a]pyrazine
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IFLAB-BB F1962-0261
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