7,8-DIHYDROXY-3-(4-HYDROXY-PHENYL)-CHROMEN-4-ONE
Synonym(s):7,8-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;7,8-Dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one, 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 Inhibitor, YN1;PFKFB3 Inhibitor III, YN1 - CAS 75187-63-2 - Calbiochem
- CAS NO.：75187-63-2
- Empirical Formula: C15H10O5
- Molecular Weight: 270.24
- MDL number: MFCD00885567
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:42
What is 7,8-DIHYDROXY-3-(4-HYDROXY-PHENYL)-CHROMEN-4-ONE?
Definition
ChEBI: 8-Hydroxydaidzein is a member of isoflavones.
Biochem/physiol Actions
YN1 is a potent inhibitor of PFKFB3 (6-Phosphfructo-2-kinase/fructose-2,6-bisphosphatase: IC50 = 670 nM). PFKFB3 is over expressed in many cancers, and catalyzes the production of fructose-2,6-bisphosphate, which can potentiate PFK1 activity, enhancing glycolysis in tumor cells. YN1 inhibits glycolysis and proliferation in HeLa cells.
Properties of 7,8-DIHYDROXY-3-(4-HYDROXY-PHENYL)-CHROMEN-4-ONE
| storage temp. | 2-8°C |
| solubility | DMSO: soluble10mg/mL, clear |
| form | powder |
| color | white to beige |
Safety information for 7,8-DIHYDROXY-3-(4-HYDROXY-PHENYL)-CHROMEN-4-ONE
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral |
| Precautionary Statement Codes |
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for 7,8-DIHYDROXY-3-(4-HYDROXY-PHENYL)-CHROMEN-4-ONE
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product: 75187-63-2 7,8,4'-Trihydroxyisoflavone 98%
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