7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one
- CAS NO.：199327-61-2
- Empirical Formula: C16H21N3O4
- Molecular Weight: 319.36
- MDL number: MFCD12760130
- EINECS: 429-400-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-12 17:58:41
What is 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one?
Description
7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one is a pharmaceutical intermediate used in the preparation of gefitinib, an orally active selective inhibitor of the epidermal growth factor receptor tyrosine kinase, an enzyme that regulates intracellular signalling pathways that associated with the proliferation and survival of cancer cells.
Chemical properties
White Solid
The Uses of 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one
Gefitinib intermediate.
Properties of 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one
| Melting point: | 233-236 °C |
| Boiling point: | 519.5±60.0 °C(Predicted) |
| Density | 1.32±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 7.10±0.10(Predicted) |
| color | White to Off-White |
| CAS DataBase Reference | 199327-61-2(CAS DataBase Reference) |
Safety information for 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P312:Call a POISON CENTER or doctor/physician if you feel unwell. |
Computed Descriptors for 7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one
7-Methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4(3H)-one manufacturer
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