7-Ethoxycoumarin
Synonym(s):7-Ethoxy-1-benzopyran-2-one
- CAS NO.:31005-02-4
- Empirical Formula: C11H10O3
- Molecular Weight: 190.2
- MDL number: MFCD00006877
- EINECS: 250-429-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-08 20:21:46
What is 7-Ethoxycoumarin?
Chemical properties
BEIGE CRYSTALLINE POWDER
The Uses of 7-Ethoxycoumarin
7-Ethoxycoumarin is commonly used for metabolism studies, including hepatocyte studies, liver perfusion techniques and cytochrome P450 studies.
7-Ethoxycoumarin has been used to study the functional activity of recombinant P450. ) It has also been used as an internal standard for in vitro S-warfarin 7-hydroxylation and high performance liquid chromatography (HPLC) analysis.
The Uses of 7-Ethoxycoumarin
7-Ethoxycoumarin is a substrate for CYP2B6 used in fluorometric assays of microsomal monooxygenase activity.
What are the applications of Application
7-Ethoxycoumarin is a substrate for CYP2B6
Definition
ChEBI: 7-ethoxycoumarin is a member of the class of coumarins that is umbelliferone in which the hydroxy group at position 7 is replaced by an ethoxy group. It is an aromatic ether and a member of coumarins. It derives from an umbelliferone.
Biochem/physiol Actions
7-Ethoxycoumarin is a cytochrome P450 substrate.
Metabolism
7-Ethoxycoumarin is metabolized by many cytochrome P450 enzymes active in foreign compound metabolism and has been used as a prototypic substrate to monitor P450 (P450) activity in both hepatic and extrahepatic tissues.
The in vitro perfusion of the human placental lobule with 7-ethoxycoumarin gives 7-hydroxycoumarin, and perfusion with androstenedione gives the conversion products, estrone, estradiol, and testosterone. The human placenta has only a limited capacity for the metabolism of xenobiotics.
Use of 7-Ethoxycoumarin to Monitor Multiple Enzymes in the Human CYP1, CYP2, and CYP3 Families
Properties of 7-Ethoxycoumarin
Melting point: | 88-90 °C (lit.) |
Boiling point: | 265.69°C (rough estimate) |
Density | 1.1803 (rough estimate) |
refractive index | 1.4260 (estimate) |
storage temp. | Sealed in dry,Room Temperature |
solubility | Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly) |
form | Solid |
color | Off-White to Pale Brown |
Water Solubility | Soluble in hot methanol (very faint turbidity), 95% ethanol (50 mg/ml), DMF, and DMSO. Insoluble in water. |
BRN | 146200 |
CAS DataBase Reference | 31005-02-4(CAS DataBase Reference) |
Safety information for 7-Ethoxycoumarin
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for 7-Ethoxycoumarin
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