Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name list7-Ethoxycoumarin

7-Ethoxycoumarin

Synonym(s):7-Ethoxy-1-benzopyran-2-one

  • CAS NO.:31005-02-4
  • Empirical Formula: C11H10O3
  • Molecular Weight: 190.2
  • MDL number: MFCD00006877
  • EINECS: 250-429-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
7-Ethoxycoumarin Structural

What is 7-Ethoxycoumarin?

Chemical properties

BEIGE CRYSTALLINE POWDER

The Uses of 7-Ethoxycoumarin

7-Ethoxycoumarin is commonly used for metabolism studies, including hepatocyte studies, liver perfusion techniques and cytochrome P450 studies.
7-Ethoxycoumarin has been used to study the functional activity of recombinant P450. ) It has also been used as an internal standard for in vitro S-warfarin 7-hydroxylation and high performance liquid chromatography (HPLC) analysis.

The Uses of 7-Ethoxycoumarin

7-Ethoxycoumarin is a substrate for CYP2B6 used in fluorometric assays of microsomal monooxygenase activity.

What are the applications of Application

7-Ethoxycoumarin is a substrate for CYP2B6

Definition

ChEBI: 7-ethoxycoumarin is a member of the class of coumarins that is umbelliferone in which the hydroxy group at position 7 is replaced by an ethoxy group. It is an aromatic ether and a member of coumarins. It derives from an umbelliferone.

Biochem/physiol Actions

7-Ethoxycoumarin is a cytochrome P450 substrate.

Metabolism

7-Ethoxycoumarin is metabolized by many cytochrome P450 enzymes active in foreign compound metabolism and has been used as a prototypic substrate to monitor P450 (P450) activity in both hepatic and extrahepatic tissues.
The in vitro perfusion of the human placental lobule with 7-ethoxycoumarin gives 7-hydroxycoumarin, and perfusion with androstenedione gives the conversion products, estrone, estradiol, and testosterone. The human placenta has only a limited capacity for the metabolism of xenobiotics.
Use of 7-Ethoxycoumarin to Monitor Multiple Enzymes in the Human CYP1, CYP2, and CYP3 Families

Properties of 7-Ethoxycoumarin

Melting point: 88-90 °C (lit.)
Boiling point: 265.69°C (rough estimate)
Density  1.1803 (rough estimate)
refractive index  1.4260 (estimate)
storage temp.  Sealed in dry,Room Temperature
solubility  Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
form  Solid
color  Off-White to Pale Brown
Water Solubility  Soluble in hot methanol (very faint turbidity), 95% ethanol (50 mg/ml), DMF, and DMSO. Insoluble in water.
BRN  146200
CAS DataBase Reference 31005-02-4(CAS DataBase Reference)

Safety information for 7-Ethoxycoumarin

Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for 7-Ethoxycoumarin

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.