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HomeProduct name list7-Ethoxycoumarin

7-Ethoxycoumarin

Synonym(s):7-Ethoxy-1-benzopyran-2-one

  • CAS NO.:31005-02-4
  • Empirical Formula: C11H10O3
  • Molecular Weight: 190.2
  • MDL number: MFCD00006877
  • EINECS: 250-429-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-08 20:21:46
7-Ethoxycoumarin Structural

What is 7-Ethoxycoumarin?

Chemical properties

BEIGE CRYSTALLINE POWDER

The Uses of 7-Ethoxycoumarin

7-Ethoxycoumarin is commonly used for metabolism studies, including hepatocyte studies, liver perfusion techniques and cytochrome P450 studies.
7-Ethoxycoumarin has been used to study the functional activity of recombinant P450. ) It has also been used as an internal standard for in vitro S-warfarin 7-hydroxylation and high performance liquid chromatography (HPLC) analysis.

The Uses of 7-Ethoxycoumarin

7-Ethoxycoumarin is a substrate for CYP2B6 used in fluorometric assays of microsomal monooxygenase activity.

What are the applications of Application

7-Ethoxycoumarin is a substrate for CYP2B6

Definition

ChEBI: 7-ethoxycoumarin is a member of the class of coumarins that is umbelliferone in which the hydroxy group at position 7 is replaced by an ethoxy group. It is an aromatic ether and a member of coumarins. It derives from an umbelliferone.

Biochem/physiol Actions

7-Ethoxycoumarin is a cytochrome P450 substrate.

Metabolism

7-Ethoxycoumarin is metabolized by many cytochrome P450 enzymes active in foreign compound metabolism and has been used as a prototypic substrate to monitor P450 (P450) activity in both hepatic and extrahepatic tissues.
The in vitro perfusion of the human placental lobule with 7-ethoxycoumarin gives 7-hydroxycoumarin, and perfusion with androstenedione gives the conversion products, estrone, estradiol, and testosterone. The human placenta has only a limited capacity for the metabolism of xenobiotics.
Use of 7-Ethoxycoumarin to Monitor Multiple Enzymes in the Human CYP1, CYP2, and CYP3 Families

Properties of 7-Ethoxycoumarin

Melting point: 88-90 °C (lit.)
Boiling point: 265.69°C (rough estimate)
Density  1.1803 (rough estimate)
refractive index  1.4260 (estimate)
storage temp.  Sealed in dry,Room Temperature
solubility  Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
form  Solid
color  Off-White to Pale Brown
Water Solubility  Soluble in hot methanol (very faint turbidity), 95% ethanol (50 mg/ml), DMF, and DMSO. Insoluble in water.
BRN  146200
CAS DataBase Reference 31005-02-4(CAS DataBase Reference)

Safety information for 7-Ethoxycoumarin

Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for 7-Ethoxycoumarin

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