Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name list7-AMINOACTINOMYCIN D

7-AMINOACTINOMYCIN D

Synonym(s):7-AAD;7-AAD, 7-Amino-AMD, 7-Aminoactinomycin C₁, 7-Aminodactinomycin;Actinomycin D, 7-Amino- - CAS 7240-37-1 - Calbiochem

  • CAS NO.:7240-37-1
  • Empirical Formula: C62H87N13O16
  • Molecular Weight: 1270.43
  • MDL number: MFCD00077295
  • EINECS: 635-285-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-23 13:36:13
7-AMINOACTINOMYCIN D Structural

What is 7-AMINOACTINOMYCIN D?

Description

7-Aminoactinomycin D (7-AAD) is a fluorescent DNA dye that is commonly used for the detection or exclusion of non-viable cells in flow cytometric analysis, as it is generally excluded by live cells. It displays excitation spectra of 488, 546, and 578 nm and an emission spectrum of 650 nm. As 7-AAD is detected in the far red range of the spectrum, it exhibits minimal spectral overlap with commonly used probes, therefore it can be used in conjunction with probes such as FITC. 7-AAD has been used to evaluate apoptosis and cell-mediated cytotoxicity and to stain DNA in cells that have been fixed and permeabilized by a variety of methods.

Chemical properties

Purple powder

The Uses of 7-AMINOACTINOMYCIN D

7-Aminoactinomycin D is a fluorescent DNA dye for apoptosis and flow cytomtery studies.

The Uses of 7-AMINOACTINOMYCIN D

Fluorescent DNA stain. A featured product for Apoptosis research.

What are the applications of Application

7-Aminoactinomycin D is a fluorescent DNA dye for apoptosis and flow cytomtery studies

Definition

ChEBI: 7-aminoactinomycin D is a chromopeptide. It has a role as a fluorochrome.

General Description

Free form:
Excitation: 503 nm (0.01 M phosphate buffer, pH 7.0 containing 0.1 mM EDTA); 550 nm
Emission: 675 nm (0.01 M phosphate buffer, pH 7.0 containing 0.1 mM EDTA); 672 nm
DNA Complex:
Excitation: 543 nm; 555 nm
Emission: 655 nm; 665 nm

Biochem/physiol Actions

Primary Targetleukemias and sarcomas

storage

Store at -20°C

References

1) Telieps?et al.?(2013)?Cellular-FLIP, Raji isoform (c-FLIP R) modulates cell death induction upon T-cell activation and infection, Eur. J. Immunol. 43 1499 2) Schmid?et al.?(2007)?Live-cell assay for detection of apoptosis by dual-laser flow cytometry using Hoechst 33342 and 7-amino-actinomycin D, Nat. Protoc.?2?187 3) Toba?et al.?(2000) Cell kinetic study of normal human bone marrow hematopoiesis and acute leukemia using 7AAD/PY, Eur.J.Haematol. 64 10 4) Lecoeur?et al.?(1997)?Strategies for phenotyping apoptotic peripheral human lymphocytes comparing ISNT, annexin-V and 7-AAD cytofluorometric staining methods, J. Immunol. Methods?209?111 5) Su?et al.?(1996)?Hematopoietic cell protein-tyrosine phosphatase-deficient motheaten mice exhibit T cell apoptosis defect, J. Immunol.?156?4198

Properties of 7-AMINOACTINOMYCIN D

Melting point: 252~253℃
Boiling point: 1400.8±65.0 °C(Predicted)
Density  1.44
Flash point: 801℃
storage temp.  -20°C
solubility  chloroform: 1 mg/mL, clear, red
form  powder
pka 8.90±0.70(Predicted)
color  red to dark purple
BRN  5915844
Stability: Stable for 1 year from date of purchase as supplied. Solutions should be made fresh daily.

Safety information for 7-AMINOACTINOMYCIN D

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
GHS Hazard Statements H300:Acute toxicity,oral
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405:Store locked up.
P501:Dispose of contents/container to..…

Computed Descriptors for 7-AMINOACTINOMYCIN D

Related products of tetrahydrofuran

You may like

  • 7-Aminoactinomycin D CAS 7240-37-1
    7-Aminoactinomycin D CAS 7240-37-1
    7240-37-1
    View Details
  • 1-Methyl-6-oxo-1,6-dihydropyridazine-3-carbonitrile 98%
    1-Methyl-6-oxo-1,6-dihydropyridazine-3-carbonitrile 98%
    99903-60-3
    View Details
  • 1823368-42-8 98%
    1823368-42-8 98%
    1823368-42-8
    View Details
  • 2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%
    2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%
    1307449-08-6
    View Details
  • Ethyl 3-(furan-2-yl)-3-hydroxypropanoate 25408-95-1 98%
    Ethyl 3-(furan-2-yl)-3-hydroxypropanoate 25408-95-1 98%
    25408-95-1
    View Details
  • 2-Chloro-5-fluoro-1-methoxy-3-methylbenzene 98%
    2-Chloro-5-fluoro-1-methoxy-3-methylbenzene 98%
    1805639-70-6
    View Details
  • 1784294-80-9 98%
    1784294-80-9 98%
    1784294-80-9
    View Details
  • Lithium Clavulanate
    Lithium Clavulanate
    61177-44-4
    View Details
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.