(6AS-TRANS)-11-CHLORO-6,6A,7,8,9,13B-HEXAHYDRO-7-METHYL-5H-BENZO[D]NAPHTH[2,1-B]AZEPIN-12-OL HYDROBROMIDE

CAS NO.：1227675-51-5
Empirical Formula: C19H21BrClNO
Molecular Weight: 394.74
MDL number: MFCD08703109
Update Date: 2023-06-30 15:45:59

What is (6AS-TRANS)-11-CHLORO-6,6A,7,8,9,13B-HEXAHYDRO-7-METHYL-5H-BENZO[D]NAPHTH[2,1-B]AZEPIN-12-OL HYDROBROMIDE?

Description

SCH 39166 is a dopamine D₁ receptor antagonist (K_i = 5 nM). It is selective for D₁ over D_2-4 receptors (K_is = 3,751, >1,000, and 5,934 nM, respectively), however, it also binds to D₅ receptors (K_i = 4.4 nM). SCH 39166 inhibits food intake in a dose-dependent manner in rats (ED₅₀ = 0.84 mg/kg). It reduces ethanol intake in Sardinian alcohol-preferring rats and sucrose intake in water-deprived and water-sated rats without affecting food or total fluid intake. SCH 39166 also suppresses cocaine-induced arrhythmias in anesthetized dogs.

The Uses of (6AS-TRANS)-11-CHLORO-6,6A,7,8,9,13B-HEXAHYDRO-7-METHYL-5H-BENZO[D]NAPHTH[2,1-B]AZEPIN-12-OL HYDROBROMIDE

SCH 39166 is a dopamine D1/D5 receptor antagonist used in the treatment of schizophrenia, cocaine addiction and obesity.

What are the applications of Application

SCH 39166 hydrobromide is a high affinity D1DR/D5DR antagonist

storage

Desiccate at RT

Properties of (6AS-TRANS)-11-CHLORO-6,6A,7,8,9,13B-HEXAHYDRO-7-METHYL-5H-BENZO[D]NAPHTH[2,1-B]AZEPIN-12-OL HYDROBROMIDE

storage temp.	Desiccate at RT
solubility	DMSO: Slightly Soluble; Methanol: Slightly Soluble; Water: Slightly Soluble
form	A solid
Stability:	Hygroscopic

Safety information for (6AS-TRANS)-11-CHLORO-6,6A,7,8,9,13B-HEXAHYDRO-7-METHYL-5H-BENZO[D]NAPHTH[2,1-B]AZEPIN-12-OL HYDROBROMIDE

Computed Descriptors for (6AS-TRANS)-11-CHLORO-6,6A,7,8,9,13B-HEXAHYDRO-7-METHYL-5H-BENZO[D]NAPHTH[2,1-B]AZEPIN-12-OL HYDROBROMIDE

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