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HomeProduct name list6,2',4'-TRIMETHOXYFLAVONE

6,2',4'-TRIMETHOXYFLAVONE

Synonym(s):2-(2,4-Dimethoxyphenyl)-2,3-dihydro-6-methoxy-4H-1-benzopyran-4-one;TMF;Trimethoxyflavone

6,2',4'-TRIMETHOXYFLAVONE Structural

What is 6,2',4'-TRIMETHOXYFLAVONE?

What are the applications of Application

6,2′,4′-Trimethoxyflavone is an aryl hydrocarbon receptor inhibitor

Biochem/physiol Actions

6, 2′, 4′-trimethoxyflavone is a selective aryl hydrocarbon receptor (AHR) antagonist with no partial agonist activity. The role of the transcription factor aryl hydrocarbon receptor (AHR) in biology is still under evaluation and has expanded beyond that of a xenobiotic sensor and regulator of detoxification. Inhibition of AHR activity by antagonists could result in anti-inflammatory actions. 6, 2′, 4′-trimethoxyflavone (TMF) is a pure AHR antagonist. The compound compete with agonists, such as 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) and benzo[a]pyrene (B[a]P), thus effectively inhibiting AHRmediated transactivation of a heterologous reporter and endogenous targets e.g. CYP1A1. TMF also exhibits no species or promoter dependency with regard to AHR antagonism. Thus it represents an improved tool allowing for more precise dissection of AHR function.

Properties of 6,2',4'-TRIMETHOXYFLAVONE

Boiling point: 482.8±45.0 °C(Predicted)
Density  1.208±0.06 g/cm3(Predicted)
storage temp.  room temp
solubility  DMSO: >5mg/mL
form  powder
color  yellow

Safety information for 6,2',4'-TRIMETHOXYFLAVONE

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
GHS Hazard Statements H301:Acute toxicity,oral
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P405:Store locked up.
P501:Dispose of contents/container to..…

Computed Descriptors for 6,2',4'-TRIMETHOXYFLAVONE

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