6,2',4'-TRIMETHOXYFLAVONE
Synonym(s):2-(2,4-Dimethoxyphenyl)-2,3-dihydro-6-methoxy-4H-1-benzopyran-4-one;TMF;Trimethoxyflavone
- CAS NO.:720675-90-1
- Empirical Formula: C18H18O5
- Molecular Weight: 314.33
- MDL number: MFCD03412381
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is 6,2',4'-TRIMETHOXYFLAVONE?
What are the applications of Application
6,2′,4′-Trimethoxyflavone is an aryl hydrocarbon receptor inhibitor
Biochem/physiol Actions
6, 2′, 4′-trimethoxyflavone is a selective aryl hydrocarbon receptor (AHR) antagonist with no partial agonist activity. The role of the transcription factor aryl hydrocarbon receptor (AHR) in biology is still under evaluation and has expanded beyond that of a xenobiotic sensor and regulator of detoxification. Inhibition of AHR activity by antagonists could result in anti-inflammatory actions. 6, 2′, 4′-trimethoxyflavone (TMF) is a pure AHR antagonist. The compound compete with agonists, such as 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) and benzo[a]pyrene (B[a]P), thus effectively inhibiting AHRmediated transactivation of a heterologous reporter and endogenous targets e.g. CYP1A1. TMF also exhibits no species or promoter dependency with regard to AHR antagonism. Thus it represents an improved tool allowing for more precise dissection of AHR function.
Properties of 6,2',4'-TRIMETHOXYFLAVONE
Boiling point: | 482.8±45.0 °C(Predicted) |
Density | 1.208±0.06 g/cm3(Predicted) |
storage temp. | room temp |
solubility | DMSO: >5mg/mL |
form | powder |
color | yellow |
Safety information for 6,2',4'-TRIMETHOXYFLAVONE
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 |
GHS Hazard Statements |
H301:Acute toxicity,oral |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P405:Store locked up. P501:Dispose of contents/container to..… |
Computed Descriptors for 6,2',4'-TRIMETHOXYFLAVONE
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