6-Hydroxypurine
Synonym(s):6-Hydroxypurine;Hypoxanthine;Hypoxanthine - CAS 68-94-0 - Calbiochem
- CAS NO.：68-94-0
- Empirical Formula: C5H4N4O
- Molecular Weight: 136.11
- MDL number: MFCD00005725
- EINECS: 200-697-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-08 17:36:13
What is 6-Hydroxypurine?
Description
Hypoxanthine is a naturally occurring purine derivative and intermediate in the synthesis of uric acid. It is elevated in the spinal fluid of patients with Lesch-Nyhan syndrome, a metabolic disorder whose symptoms include cerebral palsy, cognitive deficits, motor dysfunction, self-mutilation, and hyperuricemia. Injection of hypoxanthine (10 μM) increases succinate dehydrogenase and complex II activities and decreases cytochrome c oxidase activity, resulting in neuroenergetic impairment, ATP depletion, and cellular apoptosis in rat striatum. It is also used to induce hyperuricemia in mice for use in the development of hypouricemic agents.
The Uses of 6-Hydroxypurine
A naturally occurring purine derivative. Pharmaceuticals, Intermediates & Fine Chemicals
What are the applications of Application
Hypoxanthine is a marker for energy perturbation in hypoxia/ ischemia
Properties of 6-Hydroxypurine
| Melting point: | >300 °C (lit.) |
| Boiling point: | 250.36°C (rough estimate) |
| Density | 1.4295 (rough estimate) |
| storage temp. | 2-8°C |
| solubility | 1 M NaOH: 25 mg/mL |
| form | powder |
| color | Colorless to yellow to brown, darken on storage with no loss of purity |
| Odor | Odorless |
| Water Solubility | practically insoluble |
Safety information for 6-Hydroxypurine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P312:Call a POISON CENTER or doctor/physician if you feel unwell. P330:Rinse mouth. P302+P352:IF ON SKIN: wash with plenty of soap and water. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. |
Computed Descriptors for 6-Hydroxypurine
| InChIKey | FDGQSTZJBFJUBT-UHFFFAOYSA-N |
Abamectin manufacturer
OPULENT PHARMA
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Phone:+91-9106692785
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product: 68-94-0 Azathioprine EP Impurity F (Didanosine EP Impurity A/ Didanosine Related Compound A/ Hypoxanthine) 98%
Vijaya Pharma And Life Science
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Phone:+91-8939866271
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product: Hypoxanthine 68-94-0 / 51953-23-2 98%
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