6-Hydroxyindole
Synonym(s):6-Indolol
- CAS NO.：2380-86-1
- Empirical Formula: C8H7NO
- Molecular Weight: 133.15
- MDL number: MFCD00152101
- EINECS: 417-020-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-29 14:36:51
What is 6-Hydroxyindole?
Chemical properties
White to off-white shiny crystalline powder
The Uses of 6-Hydroxyindole
- Reactant for preparation of tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles as potential anticancer immunomodulators
- Reactant for asymmetrical synthesis of notoamide J as a potential biosynthetic precursor of prenylated indole alkaloids
- Reactant for preparation of (quinolinyloxymethyl)isoxazolecarboxylate esters antituberculosis agents
- Reactant for preparation of indolyl(propanolamine) derivatives as HIV inhibitors
- Reactant for preparation of indoleoxyacetic acid derivatives as peroxisome proliferator-activated receptor agonists
- Reactant for preparation of 1-aroylindole 3-aroylindoles combretastatin A-4 analogs as antitumor agents and tubulin polymerization inhibitors
What are the applications of Application
6-Hydroxyindole is a reactant for asymmetrical synthesis of notoamide J
Synthesis Reference(s)
Journal of Medicinal Chemistry, 35, p. 2419, 1992 DOI: 10.1021/jm00091a010
Properties of 6-Hydroxyindole
| Melting point: | 125-128 °C |
| Boiling point: | 343.2±15.0 °C(Predicted) |
| Density | 1.327±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Chloroform (Slightly, Heated), Methanol (Slightly) |
| pka | 10.07±0.40(Predicted) |
| form | Shiny Crystalline Powder |
| color | White to off-white |
| CAS DataBase Reference | 2380-86-1(CAS DataBase Reference) |
Safety information for 6-Hydroxyindole
| Signal word | Danger |
| Pictogram(s) |
 Corrosion Corrosives GHS05  Exclamation Mark Irritant GHS07  Environment GHS09 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H317:Sensitisation, Skin H318:Serious eye damage/eye irritation H411:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 6-Hydroxyindole
| InChIKey | XAWPKHNOFIWWNZ-UHFFFAOYSA-N |
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