6-Hydroxy-1-tetralone

Synonym(s):6-Hydroxy-1-tetralone

CAS NO.：3470-50-6
Empirical Formula: C10H10O2
Molecular Weight: 162.19
MDL number: MFCD00156670
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-21 22:41:43

What is 6-Hydroxy-1-tetralone?

Chemical properties

gray powder

The Uses of 6-Hydroxy-1-tetralone

6-Hydroxy-1-tetralone is used as a starting material for a one-pot conversion of phenols to anilines.

The Uses of 6-Hydroxy-1-tetralone

6-Hydroxy-3,4-dihydro-1(2H)-naphthalenone (6-Hydroxy-1-tetralone) may be used in the synthesis of:

5-chloromethyl-6-hydroxy-3,4-dihydro-1(2H)-naphthalenone
6-(4-(3-(piperidin-1-yl)propoxy)benzyloxy)-1-tetralone
6-(3-(piperidin-1-yl)propoxy)-1-tetralone

Synthesis Reference(s)

Journal of Medicinal Chemistry, 41, p. 1068, 1998 DOI: 10.1021/jm970527v
Journal of the American Chemical Society, 99, p. 5810, 1977 DOI: 10.1021/ja00459a052

General Description

6-Hydroxy-3,4-dihydro-1(2H)-naphthalenone (6-Hydroxy-1-tetralone) can be prepared by the demethylation of 6-methoxy-3,4-dihydro-1(2H)-naphthalenone. It participates in the synthesis of 2-alkylamino-6-hydroxy-5-hydroxymethyl-1,2,3,4-tetrahydro-1-naphthalenols. Its pKa value has been reported to be 7.74.

Properties of 6-Hydroxy-1-tetralone

Melting point:	154-157 °C(lit.)
Boiling point:	358.0±31.0 °C(Predicted)
Density	1.236±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
form	Crystalline Powder
pka	8.22±0.20(Predicted)
color	Off-white to brown
CAS DataBase Reference	3470-50-6(CAS DataBase Reference)

Safety information for 6-Hydroxy-1-tetralone

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.