Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name list6-CHLORO-2-PICOLINIC ACID METHYL ESTER

6-CHLORO-2-PICOLINIC ACID METHYL ESTER

  • CAS NO.:6636-55-1
  • Empirical Formula: C7H6ClNO2
  • Molecular Weight: 171.58
  • MDL number: MFCD00155391
  • EINECS: 808-173-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-04-09 22:15:29
6-CHLORO-2-PICOLINIC ACID METHYL ESTER Structural

What is 6-CHLORO-2-PICOLINIC ACID METHYL ESTER?

The Uses of 6-CHLORO-2-PICOLINIC ACID METHYL ESTER

Methyl 6-chloropyridine-2-carboxylate was coupled with 2-(trimethylstannyl)pyridine to afford methyl 2,2?-bipyridine-6-carboxylate.

Synthesis Reference(s)

Synthetic Communications, 14, p. 77, 1984 DOI: 10.1080/00397918408060867

Synthesis

6-Chloro-2-picolinic acid methyl ester is prepared by the reaction of methanol and 6-Chloropicolinic acid. The specific synthesis steps are as follows:
Add thionyl chloride (3.7 ml, 50.8 mmol) to a solution of 6-chloropicolinic acid (4.0 g, 25.4 mmol) in methanol (85 ml) at 0 C. Stir the resultant solution for 15 minutes at 0 C, 0.5 hours at room temperature, and 6 hours at 50 C. Concentrate the reaction in vacuo and dilute with CHCl3 (150ml). Wash the organic solution with saturated aqueous sodium bicarbonate (3 x 100 ml), and brine (1 x 100 ml) and dry with sodium sulfate. Filtration and concentration afford methyl 6-chloropicolinate 4.38 g (100 percent) as a white solid. 1H NMR (CDCl3): δ 8.05 (m, 1H), 7.73 (m, 1H), 7.42 (m, 1H), 3.95 (s, 3H).
6-CHLORO-2-PICOLINIC ACID METHYL ESTER synthesis

Properties of 6-CHLORO-2-PICOLINIC ACID METHYL ESTER

Melting point: 93-94°
Boiling point: 275.8±20.0 °C(Predicted)
Density  1.294±0.06 g/cm3(Predicted)
storage temp.  Keep in dark place,Sealed in dry,Room Temperature
pka -1.03±0.10(Predicted)
form  Solid
color  Pale yellow
Water Solubility  Slightly soluble in water.

Safety information for 6-CHLORO-2-PICOLINIC ACID METHYL ESTER

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405:Store locked up.

Computed Descriptors for 6-CHLORO-2-PICOLINIC ACID METHYL ESTER

Related products of tetrahydrofuran

You may like

  • 6636-55-1 Methyl 6-chloropicolinate 99%
    6636-55-1 Methyl 6-chloropicolinate 99%
    6636-55-1
    View Details
  • Methyl 6-Chloro-2-pyridinecarboxylate CAS 6636-55-1
    Methyl 6-Chloro-2-pyridinecarboxylate CAS 6636-55-1
    6636-55-1
    View Details
  • Methyl 6-chloro-2-pyridinecarboxylate 98% (GC) CAS 6636-55-1
    Methyl 6-chloro-2-pyridinecarboxylate 98% (GC) CAS 6636-55-1
    6636-55-1
    View Details
  • 1823368-42-8 98%
    1823368-42-8 98%
    1823368-42-8
    View Details
  • 2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%
    2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%
    1307449-08-6
    View Details
  • Ethyl 3-(furan-2-yl)-3-hydroxypropanoate 25408-95-1 98%
    Ethyl 3-(furan-2-yl)-3-hydroxypropanoate 25408-95-1 98%
    25408-95-1
    View Details
  • 2-Chloro-5-fluoro-1-methoxy-3-methylbenzene 98%
    2-Chloro-5-fluoro-1-methoxy-3-methylbenzene 98%
    1805639-70-6
    View Details
  • Lithium Clavulanate
    Lithium Clavulanate
    61177-44-4
    View Details
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.