6-CHLORO-2-PICOLINIC ACID METHYL ESTER
- CAS NO.:6636-55-1
- Empirical Formula: C7H6ClNO2
- Molecular Weight: 171.58
- MDL number: MFCD00155391
- EINECS: 808-173-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-09 22:15:29
What is 6-CHLORO-2-PICOLINIC ACID METHYL ESTER?
The Uses of 6-CHLORO-2-PICOLINIC ACID METHYL ESTER
Methyl 6-chloropyridine-2-carboxylate was coupled with 2-(trimethylstannyl)pyridine to afford methyl 2,2?-bipyridine-6-carboxylate.
Synthesis Reference(s)
Synthetic Communications, 14, p. 77, 1984 DOI: 10.1080/00397918408060867
Synthesis
6-Chloro-2-picolinic acid methyl ester is prepared by the reaction of methanol and 6-Chloropicolinic acid. The specific synthesis steps are as follows:
Add thionyl chloride (3.7 ml, 50.8 mmol) to a solution of 6-chloropicolinic acid (4.0 g, 25.4 mmol) in methanol (85 ml) at 0 C. Stir the resultant solution for 15 minutes at 0 C, 0.5 hours at room temperature, and 6 hours at 50 C. Concentrate the reaction in vacuo and dilute with CHCl3 (150ml). Wash the organic solution with saturated aqueous sodium bicarbonate (3 x 100 ml), and brine (1 x 100 ml) and dry with sodium sulfate. Filtration and concentration afford methyl 6-chloropicolinate 4.38 g (100 percent) as a white solid. 1H NMR (CDCl3): δ 8.05 (m, 1H), 7.73 (m, 1H), 7.42 (m, 1H), 3.95 (s, 3H).
Properties of 6-CHLORO-2-PICOLINIC ACID METHYL ESTER
Melting point: | 93-94° |
Boiling point: | 275.8±20.0 °C(Predicted) |
Density | 1.294±0.06 g/cm3(Predicted) |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
pka | -1.03±0.10(Predicted) |
form | Solid |
color | Pale yellow |
Water Solubility | Slightly soluble in water. |
Safety information for 6-CHLORO-2-PICOLINIC ACID METHYL ESTER
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 6-CHLORO-2-PICOLINIC ACID METHYL ESTER
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ALTRAKEM PHARMA LIFE SCIENCES PRIVATE LIMITED
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