6-Chloro-1H-pyrazolo[4,3-c]pyridine
- CAS NO.:1206979-33-0
- Empirical Formula: C6H4ClN3
- Molecular Weight: 153.57
- MDL number: MFCD17010105
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-30 17:08:36
What is 6-Chloro-1H-pyrazolo[4,3-c]pyridine?
The Uses of 6-Chloro-1H-pyrazolo[4,3-c]pyridine
Used as a pharmaceutical intermediate for laboratory research and development.
Synthesis
4,6-Dichloropyridine-3-carbaldehyde (3.7 g, 32 mmol), hydrazine (3.5 mL, 110 mmol) and N,N-diisopropylethylamine (20 mL) were combined in DMA (100 mL) and stirred at 80° C. for four hours. Then, the solution was cooled to room temperature, diluted with EtOAc, and washed three times with water and then with brine. The organic solution was concentrated and the resulting mixture was precipitated from dichloromethane to give 6-chloro-1H-pyrazolo[4,3-c]pyridine. Yield 2 g (41%). LCMS (ESI): calc. C6H4ClN3=153; obs. M+H=154.
Properties of 6-Chloro-1H-pyrazolo[4,3-c]pyridine
Boiling point: | 358℃ |
Density | 1.531 |
Flash point: | 201℃ |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
pka | 10.46±0.40(Predicted) |
form | powder |
color | Yellow |
InChI | InChI=1S/C6H4ClN3/c7-6-1-5-4(2-8-6)3-9-10-5/h1-3H,(H,9,10) |
CAS DataBase Reference | 1206979-33-0 |
Safety information for 6-Chloro-1H-pyrazolo[4,3-c]pyridine
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 6-Chloro-1H-pyrazolo[4,3-c]pyridine
InChIKey | AAJIQIWPVIWCGA-UHFFFAOYSA-N |
SMILES | C1=NC(Cl)=CC2NN=CC1=2 |
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product: 1206979-33-0 6-Chloro-1H-Pyrazolo[4,3-c]Pyridine 98%
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