6-Chloro-1H-pyrazolo[4,3-c]pyridine

CAS NO.：1206979-33-0
Empirical Formula: C6H4ClN3
Molecular Weight: 153.57
MDL number: MFCD17010105
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-30 17:08:36

What is 6-Chloro-1H-pyrazolo[4,3-c]pyridine?

The Uses of 6-Chloro-1H-pyrazolo[4,3-c]pyridine

Used as a pharmaceutical intermediate for laboratory research and development.

Synthesis

4,6-Dichloropyridine-3-carbaldehyde (3.7 g, 32 mmol), hydrazine (3.5 mL, 110 mmol) and N,N-diisopropylethylamine (20 mL) were combined in DMA (100 mL) and stirred at 80° C. for four hours. Then, the solution was cooled to room temperature, diluted with EtOAc, and washed three times with water and then with brine. The organic solution was concentrated and the resulting mixture was precipitated from dichloromethane to give 6-chloro-1H-pyrazolo[4,3-c]pyridine. Yield 2 g (41%). LCMS (ESI): calc. C6H4ClN3=153; obs. M+H=154.

Properties of 6-Chloro-1H-pyrazolo[4,3-c]pyridine

Boiling point:	358℃
Density	1.531
Flash point:	201℃
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	10.46±0.40(Predicted)
form	powder
color	Yellow
InChI	InChI=1S/C6H4ClN3/c7-6-1-5-4(2-8-6)3-9-10-5/h1-3H,(H,9,10)
CAS DataBase Reference	1206979-33-0

Safety information for 6-Chloro-1H-pyrazolo[4,3-c]pyridine

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.