6-Bromoimidazo[1,2-a]pyridine

CAS NO.：6188-23-4
Empirical Formula: C7H5BrN2
Molecular Weight: 197.03
MDL number: MFCD06496200
EINECS: 689-291-9
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-25 16:21:11

What is 6-Bromoimidazo[1,2-a]pyridine?

Chemical properties

White crystalline powder

The Uses of 6-Bromoimidazo[1,2-a]pyridine

It is used in organic syntheses and as pharmaceutical intermediates. The best results were obtained with lactams that could be introduced on the 6-bromoimidazo[1,2-a]pyridine. 1,2-dihydro-5-imidazo [1,2-a]pyridin-6-yl-6-methyl-2-oxo-3-pyridinecarbonitrile hydrochloride monohydrate 6 was synthesized in 5 steps from 6-bromoimidazo[1,2-a] pyridine using [2- 14 C] cyanoacetamide as the source of the radiolabel.

Synthesis

The method for synthesizing the 6-bromoimidazo [1,2-a] pyridine comprises the following steps that 2-amidogen-5 bromine-pyridine reacts with a 40% chloroacetaldehyde aqueous solution at the temperature between 25 DEG C and 50 DEG C and after 2 to 24 hours, the 6-bromoimidazo [1,2-a] pyridine is obtained.

Properties of 6-Bromoimidazo[1,2-a]pyridine

Melting point:	76-78 °C
Boiling point:	165 °C(Press: 1.5 Torr)
Density	1.69±0.1 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
pka	5.10±0.50(Predicted)
color	Faint beige
Water Solubility	slightly soluble in water.
CAS DataBase Reference	6188-23-4(CAS DataBase Reference)

Safety information for 6-Bromoimidazo[1,2-a]pyridine

Signal word	Warning
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H301:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.