6-Bromo-5-methoxypicolinic acid

CAS NO.：54232-43-8
Empirical Formula: C7H6BrNO3
Molecular Weight: 232.03
MDL number: MFCD06655957
EINECS: 200-589-5
SAFETY DATA SHEET (SDS)
Update Date: 2024-01-16 11:33:49

What is 6-Bromo-5-methoxypicolinic acid?

Chemical properties

White solid

Synthesis

2-Bromo-3-methoxy-6-methylpyridine 760 mg (3.76 mmol) was dissolved in 15 ml of water, and to the resulting solution was added potassium permanganate (KMnO4) (1.49 g, 9.40mmol) and the mixture was heated at 80 °C for 3 hrs. After TLC was conducted, pH was adjusted to 4 with 10 percent hydrochloric acid (HCl) and filtration was conducted with celite. The filtrate was extracted with 50 ml of ethyl acetate (EA). The organic layer was treated with magnesium sulfate (MgSO4) and filtered, and the solution was concentrated to give 6-Bromo-5-methoxypicolinic acid as a white solid (665 mg, 2.87 mmol, 75 percent) without purification.

Properties of 6-Bromo-5-methoxypicolinic acid

Boiling point:	362.8±42.0 °C(Predicted)
Density	1.713±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	3.52±0.10(Predicted)
InChI	InChI=1S/C7H6BrNO3/c1-12-5-3-2-4(7(10)11)9-6(5)8/h2-3H,1H3,(H,10,11)

Safety information for 6-Bromo-5-methoxypicolinic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.