6-Bromo-1,3-dihydro-2H-indol-2-one

CAS NO.：99365-40-9
Empirical Formula: C8H6BrNO
Molecular Weight: 212.04
MDL number: MFCD02179605
EINECS: 800-899-7
SAFETY DATA SHEET (SDS)
Update Date: 2025-07-04 15:17:47

What is 6-Bromo-1,3-dihydro-2H-indol-2-one?

Chemical properties

Light yelllow crystal

The Uses of 6-Bromo-1,3-dihydro-2H-indol-2-one

6-Bromo-2-Oxindole is an indolinone derivative used for the preparation of p38α inhibitors as potential antiinflammatories.

The Uses of 6-Bromo-1,3-dihydro-2H-indol-2-one

6-Bromooxindole derivative is used in the preparation of p38alpha inhibitors as potential anti- inflammatories. It is used as an intermediate in pharmaceuticals.

Properties of 6-Bromo-1,3-dihydro-2H-indol-2-one

Melting point:	217-221 °C(lit.)
Boiling point:	343.6±42.0 °C(Predicted)
Density	1.666±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSo
form	Solid
pka	13.39±0.20(Predicted)
color	Orange
Water Solubility	Slightly soluble in water.
CAS DataBase Reference	99365-40-9(CAS DataBase Reference)

Safety information for 6-Bromo-1,3-dihydro-2H-indol-2-one

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 Environment GHS09
GHS Hazard Statements	H301:Acute toxicity,oral H312:Acute toxicity,dermal H315:Skin corrosion/irritation H317:Sensitisation, Skin H319:Serious eye damage/eye irritation H341:Germ cell mutagenicity H361:Reproductive toxicity H371:Specific target organ toxicity, single exposure H372:Specific target organ toxicity, repeated exposure H373:Specific target organ toxicity, repeated exposure H411:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P272:Contaminated work clothing should not be allowed out of the workplace. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P391:Collect spillage. Hazardous to the aquatic environment P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P333+P313:IF SKIN irritation or rash occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. P405:Store locked up.