[6-[benzoyl(methyl)amino]-5-methyl-3-pyridyl]boronic acid
- CAS NO.:446299-81-6
- Empirical Formula: C14H15BN2O3
- Molecular Weight: 270.09
- MDL number: MFCD32012267
- EINECS: 610-203-1
- Update Date: 2023-10-16 17:43:51
What is [6-[benzoyl(methyl)amino]-5-methyl-3-pyridyl]boronic acid?
The Uses of [6-[benzoyl(methyl)amino]-5-methyl-3-pyridyl]boronic acid
[6-[benzoyl(methyl)amino]-5-methyl-3-pyridyl]boronic acid can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
Synthesis
Under a nitrogen atmosphere, N-(5-bromo-3-methyl-2-pyridinyl)-N-methylbenzamide 30.0 g was dissolved in 150 mL of tetrahydrofuran, triisopropyl borate 22.0 g was added. The reaction mixture was colled to-60 .DEGREE CELSIUS., n-butyl lithium (1.56 mol/L n-hexane solution) 69 mL was added dropwise required to between 20 minutes, and the mixture was stirred for 15 minutes at the same temperature.After raising the temperature of the reaction mixture at-20 .DEGREE CELSIUS., 390 mL of water was added dropwise, it was stirred for 30 min at room temperature,the aqueous layer was separated. The aqueous layer was fractionated and HCl 1 mol/L was added to adjust the pH at 4.5,the precipitate was collected by filtration, 6-[benzoyl(methyl)amino]-5-methyl-3-pyridinylboric acid 18.5 g was obtained as colorless solid.
Properties of [6-[benzoyl(methyl)amino]-5-methyl-3-pyridyl]boronic acid
Boiling point: | 513.7±60.0 °C(Predicted) |
Density | 1.27±0.1 g/cm3(Predicted) |
vapor pressure | 0Pa at 25℃ |
form | Solid:particulate/powder |
pka | 4.12±0.18(Predicted) |
Safety information for [6-[benzoyl(methyl)amino]-5-methyl-3-pyridyl]boronic acid
Computed Descriptors for [6-[benzoyl(methyl)amino]-5-methyl-3-pyridyl]boronic acid
Abamectin manufacturer
Aventus Labs
New Products
ALUMINIUM IODIDE 100 GM BUFFER CAPSULE PH 7.0 - 10 CAP BUFFER SOLUTION PH 9.5 (BORATE) EZEE BLUE GEL STAINER BORAX CARMINE (GRENACHERS ALCOHOLIC) POTASSIUM IODATE - IODIDE SOLN 0.1 N Dabigatran Acyl-O3-D-Glucuronide Trifluoroacetic Acid Salt Isofolic Acid Dabigatran 2-O-acylglucuronide metabolite Dabigatran Acyl-?-D- glucuronide Trifluroacetic Acid Erythromycin EP Impurity A Desloratidine Related Compound ARelated products of tetrahydrofuran
You may like
-
446299-81-6 [6-(benzoylmethylamino)-5-methyl-3-pyridinyl]-Boronic acid 98%View Details
446299-81-6 -
Dechloro DesloratadineView Details
-
Dehydro DesloratadineView Details
-
Edoxaban Impurity 57View Details
2089454-69-1 -
Eltrombopag N-Oxide ImpurityView Details
2734533-17-4 -
Empagliflozin Bromo ImpurityView Details
-
Glycopyrronium Bromide EP Impurity IView Details
1404617-94-2 -
Ipratropium EP Impurity BView Details
58073-59-9