6-Azido-hexanoic acid
Synonym(s):6-Azidocaproic acid
- CAS NO.:79598-53-1
- Empirical Formula: C6H11N3O2
- Molecular Weight: 157
- MDL number: MFCD12406156
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-24 17:21:45
What is 6-Azido-hexanoic acid?
Description
6-Azido-hexanoic acid is a linker containing an azide group and a terminal carboxylic acid. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Chemical properties
Colorless to yellow oil
The Uses of 6-Azido-hexanoic acid
6-Azidohexanoic acid is a six-carbon saturated fatty acid with an ω-terminal azide group. This building block can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC), forming a stable amide bond. The terminal azide group allows conjugation with compounds containing alkyne groups through a copper(I)-catalyzed cycloaddition reaction, also known as click chemistry. 6-Azidohexanoic acid is useful for crosslinking, synthesis of chemical probes, and other bioconjugation strategies.
Properties of 6-Azido-hexanoic acid
Density | 1.074 g/mL |
storage temp. | 2-8°C |
solubility | Chloroform (Slightly), Methanol (Slightly) |
form | Oil |
color | Colourless to Pale Yellow |
Stability: | Light Sensitive |
Safety information for 6-Azido-hexanoic acid
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 6-Azido-hexanoic acid
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