6-Aminoindazole

CAS NO.：6967-12-0
Empirical Formula: C7H7N3
Molecular Weight: 133.15
MDL number: MFCD00005696
EINECS: 230-177-1
SAFETY DATA SHEET (SDS)
Update Date: 2023-06-08 17:06:38

What is 6-Aminoindazole?

Description

6-Aminoindazole is a tetronic acid derivative that has been shown to have an inhibitory effect on the activity of cyclopentyl and ethylene diamine. This drug also increases blood pressure in animals, and is found to be a potent inhibitor of thrombin receptor.

Chemical properties

light brown powder

What are the applications of Application

6-Aminoindazole is structurally similar to quinoline derivatives and has been shown to have anticancer activity in human ovarian carcinoma cells. The affinity constants for this compound are higher than those for most other compounds with anti-cancer effects, which may be due to the presence of hydrogen bonds between the nitrogen atoms and the carbonyl group.

Definition

ChEBI: 1H-indazol-6-amine is a member of indazoles.

Purification Methods

It is recrystallised from H2O or EtOH and sublimes in a vacuum. [Beilstein 25 H 317.]

Properties of 6-Aminoindazole

Melting point:	204-206 °C (dec.) (lit.)
Boiling point:	376.6±15.0 °C(Predicted)
Density	1.367±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	soluble in Methanol
form	Powder
pka	15.61±0.40(Predicted)
color	Tan
CAS DataBase Reference	6967-12-0(CAS DataBase Reference)

Safety information for 6-Aminoindazole

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.