5,15-DIPHENYL-21H,23H-PORPHINE
Synonym(s):5,15-Diphenyl-21H,23H-porphine;5,15-diphenyl-Porphine;5,15-Diphenylporphyrin;STAT3 Inhibitor VIII, 5,15-DPP - CAS 22112-89-6 - Calbiochem
- CAS NO.:22112-89-6
- Empirical Formula: C32H22N4
- Molecular Weight: 462.54
- MDL number: MFCD08276335
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 13:36:13
What is 5,15-DIPHENYL-21H,23H-PORPHINE?
What are the applications of Application
Stat3 Inhibitor VIII, 5,15-DPP is a cell permeable Stat3 binding porphyrin
Biological Activity
5,15-diphenylporphyrin (5,15-dpp) is a selective stat3-sh2 antagonist [1].stat3 is constitutively activated in many human cancers. stat3 functions as a critical mediator of oncogenic signaling through transcriptional activation of genes encoding apoptosis inhibitors, cell-cycle regulators and inducers of angiogenesis [2]. aberrant stat3 activity has been associated with transforming mechanisms induced by oncogenic tyrosine kinases [1].
in vitro
5,15-dpp directly bound to stat3 and antagonized the function of stat3-sh2. 5,15-dpp selectively antagonized stat3-sh2 with an ic50 of 0.28 μm over the other sh2-containing proteins stat1 and grb2[1]. the estimated kd values for the 5,15-dpp binding to stat3 was 880 nm. treatment with 5,15-dpp suppressed the dna binding activity of stat3 in a concentration-dependent manner. 5,15-dpp poorly inhibited stat1 with an ic50 of 10 μm and showed no effect grb2 [1].
References
[1] uehara y, mochizuki m, matsuno k, et al. novel high-throughput screening system for identifying stat3–sh2 antagonists[j]. biochemical and biophysical research communications, 2009, 380(3): 627-631.
[2] jing n, tweardy d j. targeting stat3 in cancer therapy[j]. anti-cancer drugs, 2005, 16(6): 601-607.
Properties of 5,15-DIPHENYL-21H,23H-PORPHINE
Melting point: | >200℃ |
Boiling point: | 912.3±65.0 °C(Predicted) |
Density | 1.285±0.06 g/cm3(Predicted) |
storage temp. | Sealed in dry,2-8°C |
solubility | ≤2mg/ml in dimethyl formamide |
form | Deep blue to deep purple solid |
color | Red to Dark blue to Black |
Safety information for 5,15-DIPHENYL-21H,23H-PORPHINE
Computed Descriptors for 5,15-DIPHENYL-21H,23H-PORPHINE
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