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HomeProduct name list5-Methoxyindole-3-acetonitrile

5-Methoxyindole-3-acetonitrile

Synonym(s):3-(Cyanomethyl)-5-methoxyindole

5-Methoxyindole-3-acetonitrile Structural

What is 5-Methoxyindole-3-acetonitrile?

Chemical properties

Brown powder

The Uses of 5-Methoxyindole-3-acetonitrile

5-Methoxyindole-3-acetonitrile is a versatile reactant used in the preparation of indole-N-acetic acid derivatives as aldose reductase inhibitors for diabetic complications treatment. It is also used in the synthesis of carboline analogs as potent MAPKAP-K2 inhibitors.

The Uses of 5-Methoxyindole-3-acetonitrile

Reactant for preparation of (-)- and (+)-debromoflustramine B and its analogues as selective butyrylcholinesterase inhibitors
Reactant for preparation of carboline analogs as potent MAPKAP-K2 inhibitors
Reactant for preparation of indole-N-acetic acid derivatives as aldose reductase inhibitors for diabetic complications treatment
Reactant for preparation of debromoflustramine B and labeled Me(3a)-13C-physostigmine
Reactant for preparation of physostigmine and physovenine
Reactant for preparation of phenethyl substituted indole derivatives as melatoninergic agonists and antagonists

Properties of 5-Methoxyindole-3-acetonitrile

Melting point: 65-69 °C (lit.)
Boiling point: 175-177 °C(Press: 0.01 Torr)
Density  1.224±0.06 g/cm3(Predicted)
storage temp.  -20°C Freezer
solubility  Chloroform (Slightly), Methanol (Slightly)
form  Solid
pka 16.02±0.30(Predicted)
color  Very Dark Brown
CAS DataBase Reference 2436-17-1(CAS DataBase Reference)

Safety information for 5-Methoxyindole-3-acetonitrile

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 5-Methoxyindole-3-acetonitrile

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