5-Methoxyindole-3-acetonitrile
Synonym(s):3-(Cyanomethyl)-5-methoxyindole
- CAS NO.：2436-17-1
- Empirical Formula: C11H10N2O
- Molecular Weight: 186.21
- MDL number: MFCD02094163
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is 5-Methoxyindole-3-acetonitrile?
Chemical properties
Brown powder
The Uses of 5-Methoxyindole-3-acetonitrile
5-Methoxyindole-3-acetonitrile is a versatile reactant used in the preparation of indole-N-acetic acid derivatives as aldose reductase inhibitors for diabetic complications treatment. It is also used in the synthesis of carboline analogs as potent MAPKAP-K2 inhibitors.
The Uses of 5-Methoxyindole-3-acetonitrile
Reactant for preparation of (-)- and (+)-debromoflustramine B and its analogues as selective butyrylcholinesterase inhibitors
Reactant for preparation of carboline analogs as potent MAPKAP-K2 inhibitors
Reactant for preparation of indole-N-acetic acid derivatives as aldose reductase inhibitors for diabetic complications treatment
Reactant for preparation of debromoflustramine B and labeled Me(3a)-13C-physostigmine
Reactant for preparation of physostigmine and physovenine
Reactant for preparation of phenethyl substituted indole derivatives as melatoninergic agonists and antagonists
Properties of 5-Methoxyindole-3-acetonitrile
| Melting point: | 65-69 °C (lit.) |
| Boiling point: | 175-177 °C(Press: 0.01 Torr) |
| Density | 1.224±0.06 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 16.02±0.30(Predicted) |
| color | Very Dark Brown |
| CAS DataBase Reference | 2436-17-1(CAS DataBase Reference) |
Safety information for 5-Methoxyindole-3-acetonitrile
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 5-Methoxyindole-3-acetonitrile
New Products
Tubulysin H Tubulysin I 2,2-diethoxyethanethioamide Tubulysin E Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- CYCLOBUTYLAMINE HYDROCHLORIDE Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate 2,2-Difluoropropylamine hydrochloride 3-Aminocyclobutanone hydrochloride 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Calcium Sodium Phosphosilicate IH Imeglimin Hydrochloride IH Fuel shell (R)-Methanesulfonic acid 3-(3-fluoro-4- morpholin-4-yl- phenyl)-2-oxo- oxazolidin-5-ylmethyl 2-(2,3-Dihydro- benzofuran-5-yl)-1- morpholin-4-yl- ethanethione Lubiprostone Latanoprostene Bunod Magnesium Trisilicate Flame Retardant Zinc Borate 7-Methoxyquinoline-4-carboxylic acid 7-Methoxyquinoline-4-carbonitrileRelated products of tetrahydrofuran
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