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HomeProduct name list5-INDANOL

5-INDANOL

Synonym(s):5-Hydroxyindan

  • CAS NO.:1470-94-6
  • Empirical Formula: C9H10O
  • Molecular Weight: 134.18
  • MDL number: MFCD00003802
  • EINECS: 216-006-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-12-22 17:53:22
5-INDANOL Structural

What is 5-INDANOL?

Description

5-Indanol, mp 54–55 ℃, bp 255 ℃, is produced from indan [496-11-7] by a sulfonation–alkali-fusion process. A synthesis for 1,1,3,3-tetraalkylindanols was developed by Bayer, which involves the reaction of isoolefins with secondary alkenylphenols (or compounds generating them under the reaction conditions) at 100–250 ℃ and in the presence of acidic catalysts. An example is the reaction of isobutene with bisphenol A in the presence of acid-activated clays which yields 1,1,3,3-tetramethyl-5-indanol [53718-26-6], mp 115 ℃, bp (2.66 kPa) 156 ℃, in a yield of 80% of the theoretical, and 4-tert-butylphenol as a coproduct.

Chemical properties

light brown to grey-brown crystalline powder or

The Uses of 5-INDANOL

5-Indanol is a 5-hydroxyindole analog with weak inhibitory activity against human melanoma tyrosinase. 5-Indanol is also used as a reagent in the preparation of Sodium Indanylcarbinicillin (S635000); a compound which has been shown to reduce blood pressure in mammals and also has been used as a b-lactam antibiotic.

Definition

ChEBI: A member of the class of phenols that is indan which has been hydroxylated at position 5.

Purification Methods

Crystallise 5-hydroxyindane from pet ether (m 56o) or pentane (m 59-60o). It has UV with max at 283.5nm (cyclohexane). The 3,5-dinitrobenzoyl derivative has m 156o. [Beilstein 6 III 2428, 6 IV 3829.]

Properties of 5-INDANOL

Melting point: 51-53 °C (lit.)
Boiling point: 255 °C (lit.)
Density  0.8540 (rough estimate)
refractive index  1.5630 (estimate)
Flash point: >230 °F
storage temp.  Sealed in dry,Room Temperature
solubility  6.3g/l
form  powder to crystal
pka 10.37±0.20(Predicted)
color  slightly brown
BRN  1936314
CAS DataBase Reference 1470-94-6(CAS DataBase Reference)
EPA Substance Registry System 5-Indanol (1470-94-6)

Safety information for 5-INDANOL

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
GHS Hazard Statements H311:Acute toxicity,dermal
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P312:Call a POISON CENTER or doctor/physician if you feel unwell.

Computed Descriptors for 5-INDANOL

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