5-Hydroxyindole
Synonym(s):5-Hydroxyindole;5-Indolol;NSC 87503
- CAS NO.:1953-54-4
- Empirical Formula: C8H7NO
- Molecular Weight: 133.15
- MDL number: MFCD00005677
- EINECS: 217-782-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-24 21:11:45
What is 5-Hydroxyindole?
Chemical properties
beige to brown crystalline needles or powder
The Uses of 5-Hydroxyindole
5-Hydroxyindole is a hydroxylated indole used as a building block in the preparation of various pharmaceutical compounds such as indole based neurochemicals. 5-Hydroxyindole is a metabolite of Tryptop han (T894800). 5-Hydroxyindole displayed weak inhibitory activity on human melanoma tyrosinase. 5-Hydroxyindole also showed inhibition of serotonin transport by blood platelets.
The Uses of 5-Hydroxyindole
• ;Reactant for preparation of (oxoimidazolidinyl/oxopyrimidinyl)benzenesulfonates as antitumor agents and tubulin inhibitors1• ;Reactant for preparation of anthranilic acids2• ;Reactant for preparation of indole compounds as dopamine D2 receptor antagonists3• ;Reactant for preparation of naphthalimide- or carbazole-containing human β-adrenoceptor ligands4• ;Reactant for preparation of melanins as nature-inspired radioprotectors5• ;Reactant for preparation of 5-vinyl-3-pyridinecarbonitriles as PKCθ inhibitors6
The Uses of 5-Hydroxyindole
5-Hydroxyindole is a hydroxylated indole used as a building block in the preparation of various pharmaceutical compounds such as indole based neurochemicals. 5-Hydroxyindole is a metabolite of Tryptophan (T894800). 5-Hydroxyindole displayed weak inhibitory activity on human melanoma tyrosinase. 5-Hydroxyindole also showed inhibition of serotonin transport by blood platelets.
What are the applications of Application
5-Hydroxyindole is a reactant for preparation of anthranilic acids
Definition
ChEBI: 5-hydroxyindole is a member of the class of hydroxyindoles that is 1H-indole in which the hydrogen at position 5 has been replaced by a hydroxy group. It has a role as a human metabolite.
Synthesis Reference(s)
Journal of the American Chemical Society, 76, p. 5579, 1954 DOI: 10.1021/ja01651a001
The Journal of Organic Chemistry, 49, p. 4833, 1984 DOI: 10.1021/jo00199a017
Properties of 5-Hydroxyindole
Melting point: | 106-108 °C(lit.) |
Boiling point: | 245.66°C (rough estimate) |
Density | 1.1475 (rough estimate) |
refractive index | 1.5260 (estimate) |
storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
solubility | 38g/l |
form | Crystalline Needles or Powder |
pka | 9.98±0.40(Predicted) |
color | beige |
Sensitive | Light Sensitive |
BRN | 112349 |
CAS DataBase Reference | 1953-54-4(CAS DataBase Reference) |
NIST Chemistry Reference | Indol-5-ol(1953-54-4) |
Safety information for 5-Hydroxyindole
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 5-Hydroxyindole
Abamectin manufacturer
Sunlight Active Drug Ingredients Pvt ltd
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