5-HYDROXY ISATIN
- CAS NO.：116569-09-6
- Empirical Formula: C8H5NO3
- Molecular Weight: 163.13
- MDL number: MFCD11007925
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 09:03:09
What is 5-HYDROXY ISATIN?
Biological Activity
5-hydroxy Isatin is an inhibitor of monoamine oxidase A (MAO-A; IC50 = 8.4 μM).1 It is selective for MAO-A over MAO-B (IC50 = >100 μM). 5-hydroxy Isatin (50 μM) also inhibits atrial natriuretic peptide-induced activation of particulate guanylyl cyclase in rat brain and heart membranes.2
References
1.Medvedev, A.E., Goodwin, B., Chow, A., et al.Inhibitory potency of some isatin analogues on human monoamine oxidase A and BBiochem. Pharmacol.44(3)590-592(1992) 2.Medvedev, A.E., Goodwin, B.L., Sandler, M., et al.Efficacy of isatin analogues as antagonists of rat brain and heart atrial natriuretic peptide receptors coupled to particulate guanylyl cyclaseBiochem. Pharmacol.57(8)913-915(1999)
Properties of 5-HYDROXY ISATIN
| storage temp. | -20°C |
| solubility | DMF: 3 mg/ml,DMSO: 5 mg/ml,Ethanol: insol,PBS (pH 7.2): insol |
| form | A solid |
Safety information for 5-HYDROXY ISATIN
Computed Descriptors for 5-HYDROXY ISATIN
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