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HomeProduct name list5-Hydroxy-3,4-dihydroquinolin-2(1H)-one

5-Hydroxy-3,4-dihydroquinolin-2(1H)-one

  • CAS NO.:30389-33-4
  • Empirical Formula: C9H9NO2
  • Molecular Weight: 163.17
  • MDL number: MFCD01862194
  • EINECS: 608-474-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-09-03 12:56:40
5-Hydroxy-3,4-dihydroquinolin-2(1H)-one Structural

What is 5-Hydroxy-3,4-dihydroquinolin-2(1H)-one?

Chemical properties

Off-white Solid

The Uses of 5-Hydroxy-3,4-dihydroquinolin-2(1H)-one

Carteolol (C184450) metabolite.

Definition

ChEBI: 5-hydroxy-3,4-dihydro-2(1h)-quinolinone is a quinolone and a hydroxyquinoline.

Synthesis

To a 100 ml three-necked flask were added 3,4,7,8-tetrahydro-2,5 (1 H, 6Η) -quinoline dione (0.02 mol) and cyclohexane (25 ml). After stirring to dissolve in the ice bath for 10min, slowly add a dropwise N-bromosuccinimide (0.03mol) in cyclohexane (5ml), and reflux for 3h at the end of the dropwise addition. After completion of the reaction by TLC, cool down to room temperature. Water was added (the amount was 0.7 times the volume of the reactant), and the mixture was allowed to stand with stirring. The aqueous layer was extracted with ethyl acetate (1 × the volume of the aqueous layer 4 times), and the organic layers were combined. Anhydrous sulfuric acid Calcium was dried and filtered, the filtrate was evaporated to remove the solvent, and the residue was dried to give an off-white solid as a 5-Hydroxy-3,4-dihydroquinolin-2(1H)-one (Yield 92.7percent).

Properties of 5-Hydroxy-3,4-dihydroquinolin-2(1H)-one

Melting point: 225-227°C
Boiling point: 381.2±42.0 °C(Predicted)
Density  1.282±0.06 g/cm3(Predicted)
storage temp.  Inert atmosphere,Room Temperature
solubility  DMSO (Slightly), Methanol (Slightly)
form  Solid
pka 9.63±0.20(Predicted)
color  White to Off-White
CAS DataBase Reference 30389-33-4(CAS DataBase Reference)

Safety information for 5-Hydroxy-3,4-dihydroquinolin-2(1H)-one

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for 5-Hydroxy-3,4-dihydroquinolin-2(1H)-one

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Phone:+91-7926462688
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