5-Hydroxy-3,4-dihydroquinolin-2(1H)-one
- CAS NO.:30389-33-4
- Empirical Formula: C9H9NO2
- Molecular Weight: 163.17
- MDL number: MFCD01862194
- EINECS: 608-474-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-09-03 12:56:40
What is 5-Hydroxy-3,4-dihydroquinolin-2(1H)-one?
Chemical properties
Off-white Solid
The Uses of 5-Hydroxy-3,4-dihydroquinolin-2(1H)-one
Carteolol (C184450) metabolite.
Definition
ChEBI: 5-hydroxy-3,4-dihydro-2(1h)-quinolinone is a quinolone and a hydroxyquinoline.
Synthesis
To a 100 ml three-necked flask were added 3,4,7,8-tetrahydro-2,5 (1 H, 6Η) -quinoline dione (0.02 mol) and cyclohexane (25 ml). After stirring to dissolve in the ice bath for 10min, slowly add a dropwise N-bromosuccinimide (0.03mol) in cyclohexane (5ml), and reflux for 3h at the end of the dropwise addition. After completion of the reaction by TLC, cool down to room temperature. Water was added (the amount was 0.7 times the volume of the reactant), and the mixture was allowed to stand with stirring. The aqueous layer was extracted with ethyl acetate (1 × the volume of the aqueous layer 4 times), and the organic layers were combined. Anhydrous sulfuric acid Calcium was dried and filtered, the filtrate was evaporated to remove the solvent, and the residue was dried to give an off-white solid as a 5-Hydroxy-3,4-dihydroquinolin-2(1H)-one (Yield 92.7percent).
Properties of 5-Hydroxy-3,4-dihydroquinolin-2(1H)-one
Melting point: | 225-227°C |
Boiling point: | 381.2±42.0 °C(Predicted) |
Density | 1.282±0.06 g/cm3(Predicted) |
storage temp. | Inert atmosphere,Room Temperature |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Solid |
pka | 9.63±0.20(Predicted) |
color | White to Off-White |
CAS DataBase Reference | 30389-33-4(CAS DataBase Reference) |
Safety information for 5-Hydroxy-3,4-dihydroquinolin-2(1H)-one
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for 5-Hydroxy-3,4-dihydroquinolin-2(1H)-one
Abamectin manufacturer
STELLENCE PHARMSCIENCE PVT TLD
JSK Chemicals
Stereokem Pvt Ltd
Rivashaa Agrotech Biopharma Pvt. Ltd.
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