5-Fluoroorotic acid
- CAS NO.:703-95-7
- Empirical Formula: C5H3FN2O4
- Molecular Weight: 174.09
- MDL number: MFCD00042526
- EINECS: 211-876-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-21 22:41:43
What is 5-Fluoroorotic acid ?
Chemical properties
White to Off-White Crystalline Solid
The Uses of 5-Fluoroorotic acid
5-FOA(5-Fluoroorotic acid ) has become a valuable tool for research in the field of molecular genetics. It has been employed in the selection of resistant strains of Saccharomyces cerevisiae that possess a mutant URA3 gene which renders them orotidine-5'-phosphate decarboxylase deficient. 5-FOA is coverted to 5-fluorouridine monophosphate (5-FUMP) in yeast cells, which can become incorporated into RNA or metabolized to the highly toxic 5-fluoro-2’-deoxyuridine monophosphate (5-FdUMP). 5-FdUMP is a potent inhibitor of thymidylate synthase (TS), causing the cessation of DNA synthesis. More recently, 5-FOA has been shown to possess potent antimalarial activity against both chloroquine-susceptible and chloroquine-resistant clones of Plasmodium falciparum. Studies indicate that TS is the primary target of 5-FOA in malarial parasites. The combination of 5-FOA and uracil has been effective in treating mice infected with Plasmodium yoelli. 5-FOA may also have potential in the treatment of human malarial infections when used in combination with other agents.
The Uses of 5-Fluoroorotic acid
Useful in the selection of orotidine-5′-phosphate decarboxylase mutants of Saccharomyces cerevisiae.
What are the applications of Application
5-Fluoroorotic acid is a product for proteomics research
Properties of 5-Fluoroorotic acid
Melting point: | 278 °C (dec.)(lit.) |
Boiling point: | 143°C (rough estimate) |
Density | 1.6154 (estimate) |
storage temp. | Sealed in dry,Store in freezer, under -20°C |
solubility | NH4OH 4 M: 50 mg/mL, clear, faintly yellow |
pka | 2.04±0.20(Predicted) |
color | Pale yellow |
Merck | 14,4176 |
CAS DataBase Reference | 703-95-7(CAS DataBase Reference) |
Safety information for 5-Fluoroorotic acid
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P501:Dispose of contents/container to..… |
Computed Descriptors for 5-Fluoroorotic acid
InChIKey | LODRRYMGPWQCTR-UHFFFAOYSA-N |
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