5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE

Synonym(s):5-Ethyl-4-(4ʹ-methoxyphenyl)-thiazolyl-2-amine, CBFα-CBFβ Inhibitor I, CBFβ-Runx1 Inhibitor I;CBFβ Inhibitor - CAS 493028-20-9 - Calbiochem

CAS NO.：493028-20-9
Empirical Formula: C12H14N2OS
Molecular Weight: 234.32
MDL number: MFCD02232182
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 23:02:33

5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE Structural

What is 5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE?

Description

Core binding factors (CBFs) are heterodimeric transcription factors consisting of a DNA-binding CBFα component (a RUNX protein) and an enhancer of binding, CBFβ. CBF dimers have central roles in hematopoiesis and, when dysfunctional, in leukemias. CBFβ inhibitor is a small molecule that binds to CBFβ and inhibits its association with Runx1 (IC₅₀ = 3.2 μM). It blocks CBFβ-Runx1 interactions in ME-1 cells, acute myeloid leukemia cells harboring dysfunctional CBF, reducing proliferation without toxicity.

The Uses of 5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE

Core binding factors (CBFs) are heterodimeric transcription factors consisting of a DNA-binding CBFα component (a RUNX protein) and an enhancer of binding, CBFβ. CBF dimers have central roles in hematopoiesis and, when dysfunctional, in leukemias. CBFβ inhibitor is a small molecule that binds to CBFβ and inhibits its association with Runx1 (IC50 = 3.2 μM). It blocks CBFβ-Runx1 interactions in ME-1 cells, acute myeloid leukemia cells harboring dysfunctional CBF, reducing proliferation without toxicity.

What are the applications of Application

CBFβ Inhibitor is a cell-permeable inhibitor of CBF that binds allosterically

Properties of 5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE

Boiling point:	421.6±40.0 °C(Predicted)
Density	1.192±0.06 g/cm3(Predicted)
storage temp.	+2C to +8C
solubility	DMF: 50 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 30 mg/ml; Ethanol: 25 mg/ml
form	Tan solid
pka	5.00±0.10(Predicted)

Safety information for 5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE

Computed Descriptors for 5-ETHYL-4-(4-METHOXY-PHENYL)-THIAZOL-2-YLAMINE

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