(5-BROMOPYRAZIN-2-YL)CARBAMIC ACID TERT-BUTYL ESTER

CAS NO.：914349-79-4
Empirical Formula: C9H12BrN3O2
Molecular Weight: 274.11
MDL number: MFCD08275683
SAFETY DATA SHEET (SDS)
Update Date: 2022-12-30 16:20:48

What is (5-BROMOPYRAZIN-2-YL)CARBAMIC ACID TERT-BUTYL ESTER?

The Uses of (5-BROMOPYRAZIN-2-YL)CARBAMIC ACID TERT-BUTYL ESTER

(5-BROMOPYRAZIN-2-YL) CARBAMIC ACID TERT-BUTYL ESTER can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Synthesis

Synthesis_914349-79-4
At 0 ??, to 5-bromopyrazine-2-amine (5736.8mg, 32.97mmol) in CH2Cl2 (80mL) solution was added 4-DMAP (403.2mg, 3.30mmol); then at 0 ?? drop two A solution of di-tert-butyl carbonate (11.4ml, 3.30mmol) in CH2Cl2; the mixture was stirred at room temperature; after the completion of the reaction was monitored by TLC, the solution was washed with brine, dried over Na2SO4, filtered, and concentrated in vacuo; the crude product was chromatographed on a silica gel column Method, purified with ethyl acetate/petroleum ether (1/2) to obtain a white solid product (7250.4 mg, yield 80.2%).

Properties of (5-BROMOPYRAZIN-2-YL)CARBAMIC ACID TERT-BUTYL ESTER

Boiling point:	295.2±40.0 °C(Predicted)
Density	1.513±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	10.75±0.70(Predicted)

Safety information for (5-BROMOPYRAZIN-2-YL)CARBAMIC ACID TERT-BUTYL ESTER

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.