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HomeProduct name list5-Bromo-7-methyl-1H-indole

5-Bromo-7-methyl-1H-indole

Synonym(s):5-Bromo-7-methyl-1H-indole

5-Bromo-7-methyl-1H-indole Structural

What is 5-Bromo-7-methyl-1H-indole?

Synthesis

5-Bromo-7-methyl-1H-indole is synthesised from 4-bromo-6-(trimethylsilylacetylenyl)-2-methylaniline by reacting with potassium tert-butyrate and sodium hydride in the presence of inert gas. The steps are as follows:
Add sodium hydride (2.64g, 0.11mol) and DMF (70mL) to a 250ml three-necked flask at room temperature and under nitrogen protection.Stir and dissolve; a solution of the compound of formula IV (14g, 0.05mol) dissolved in DMF (30mL) is slowly added dropwise to the potassium tert-butoxide solution. After the addition, the reaction system was heated to 60 degrees and kept for 2 hours. After the reaction was completed, the reaction solution was poured into ice water, extracted with methyl tert-butyl ether, and washed with sodium bicarbonate aqueous solution and brine in turn.It was then dried over anhydrous sodium sulfate, filtered, and concentrated. The crude product is purified by silica gel column chromatography to obtain the compound of 5-bromo-7-methylindole. Yield: 8.36 g, yield: 80%.
5-Bromo-7-methyl-1H-indole synthesis

Properties of 5-Bromo-7-methyl-1H-indole

Boiling point: 165 °C(Press: 0.1 Torr)
Density  1.503 g/mL at 25 °C
refractive index  n20/D1.648
Flash point: >110℃
storage temp.  Sealed in dry,Room Temperature
pka 16.34±0.30(Predicted)
form  Solid or semi-solid or lump or liquid

Safety information for 5-Bromo-7-methyl-1H-indole

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H318:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 5-Bromo-7-methyl-1H-indole

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