Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name list5-Bromo-7-azaindole

5-Bromo-7-azaindole

Synonym(s):5-Bromo-1H-pyrrolo[2,3-b]pyridine

  • CAS NO.:183208-35-7
  • Empirical Formula: C7H5BrN2
  • Molecular Weight: 197.03
  • MDL number: MFCD06659677
  • EINECS: 629-247-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-12-19 17:50:00
5-Bromo-7-azaindole Structural

What is 5-Bromo-7-azaindole?

Chemical properties

White to light brown powder or crystal

The Uses of 5-Bromo-7-azaindole

5-Bromo-7-azaindole is a chemical reagent used in organic syntheses. Used in the synthesis of Venetoclax (A112430), a potent and selective BCL-2 inhibitor that achieves potent antitumour activity while sparing platelets. Also used in other 7-azaindole derivatives such as for PDK1 inihibtors.

Synthesis

In the 250 ml flask is sequentially added in 50 ml ethanol and 5-bromo-1-hydrogen pyrrolo [2,3 - the b] pyridine -2 - ketone (4.2g, 20 mmol), Sn powder (4.7 g, 40 mmol) and 5 mol/L hydrochloric acid (14 ml), 40 ℃ stirring for 2 hours, the reaction is completed, to remove the ethanol, add 50 ml of water residue is completely dissolved, saturated NaHCO3 solution and to pH=8, and filtering the resulting solid, after drying, dissolved in 50 ml chloroform, adding CuBr2(13.4 g, 60mmol), 60 Cstirring for 2 hours, the reaction is completed, the end of the reaction, rotary evaporated to remove chloroform, adding 50 ml saturated NaHCO3 solution, ethyl acetate (3 × 100 ml), the combined organic phase with water (50 ml) for washing and then the saturated salt water (50 ml) washing, anhydrous Na2SO4 drying, filtering, the filtrate is concentrated to obtain 5-bromo-1H-pyrrolo [2,3 - the b] pyridine the crude product, the crude product is chloroform: hexane=2:1 (volume ratio) mixed solution recrystallize to get 3.1 g of pale yellow 5-Bromo-7-azaindole pure product, yield 77.6%, melting point:176.8-177.3 ℃.

Solubility in organics

The solubility of 5-Bromo-7-azaindole in pure solvents increases with increasing temperature. Among them 5-Bromo-7-azaindole showed the best solubility in methyl acetate and the worst solubility in hexane. The maximum change in solubility of 5-Bromo-7-azaindole in DCM was observed at T = 298.15-313.15 K. The solubility of 5-Bromo-7-azaindole in DCM was found to be the most variable.

Properties of 5-Bromo-7-azaindole

Melting point: 176-180 °C
Boiling point: 357.4±42.0 °C(Predicted)
Density  1.79±0.1 g/cm3(Predicted)
storage temp.  Sealed in dry,Room Temperature
form  Crystalline Powder
pka 6.25±0.20(Predicted)
color  White to yellow
InChI InChI=1S/C7H5BrN2/c8-6-3-5-1-2-9-7(5)10-4-6/h1-4H,(H,9,10)
CAS DataBase Reference 183208-35-7(CAS DataBase Reference)

Safety information for 5-Bromo-7-azaindole

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H318:Serious eye damage/eye irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for 5-Bromo-7-azaindole

InChIKey LPTVWZSQAIDCEB-UHFFFAOYSA-N
SMILES C12NC=CC1=CC(Br)=CN=2

5-Bromo-7-azaindole manufacturer

chemmolelaboratories private limited

2Y
Phone:+91-9491767516
Whatsapp: +91-9491767516
product: 5-Bromo-7-azaindole 183208-35-7 98%
Inquiry

Manik Laboratories

2Y
Phone:+91-8121482049
Whatsapp: +91- 8121482049
product: 183208-35-7 99%
Inquiry

CiVentiChem Private Limited

1Y
Phone:+91-8897000471
Whatsapp: +91 8897000471
product: 5-Bromo-7-azaindole 98%
Inquiry

Viyash Life Sciences Pvt Ltd

1Y
Phone:+91-4023635052
product: 5-Bromo-7-azaindole 183208-35-7 98%
Inquiry

Lakshmi Farmachem

1Y
Phone:+91-9550886476
Whatsapp: +91-9550886476
product: 5-Bromo-7-azaindole 98%
Inquiry

Nasense Labs Private Limited

1Y
Phone:+91-9701368505
Whatsapp: +91-970136850
product: 183208-35-7 99%
Inquiry

Sri Neelima Laboratories

1Y
Phone:+91-9849736989
Whatsapp: +91 9849736989
product: 5-Bromo-7-azaindole 99%
Inquiry

Rivashaa Agrotech Biopharma Pvt. Ltd.

1Y
Phone:+91-7926462688
product: 5-Bromo-7-azaindole 183208-35-7 98%
Inquiry

Jubilant Ingrevia

1Y
Phone:+91-1204361000
product: 183208-35-7 5-Bromo-7-azaindole 98%
Inquiry

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.