5-BROMO-1H-INDAZOL-3-AMINE

CAS NO.：61272-71-7
Empirical Formula: C7H6BrN3
Molecular Weight: 212.05
MDL number: MFCD03426696
SAFETY DATA SHEET (SDS)
Update Date: 2024-06-13 17:03:25

What is 5-BROMO-1H-INDAZOL-3-AMINE?

The Uses of 5-BROMO-1H-INDAZOL-3-AMINE

5-BROMO-1H-INDAZOL-3-AMINE can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Synthesis

Synthesis_61272-71-7
Hydrazine hydrate (18 mL) was added to Example 62C (1.93 g, 6.94 mmol.) in ethanol (10 mL). The mixture was heated to 95??C. overnight. The mixture was diluted with ethyl acetate and washed with water. Some of the product precipitated in the separatory funnel and was filtered to afford the title compound. The ethyl acetate layer was concentrated under reduced pressure and the resulting solid was triturated with methanol. 5-bromo-1H-indazol-3-amine. The title compound was prepared according to the procedure outlined in Example 62D substituting 5-bromo-2-fluorobenzonitrile for Example 62C. 1H NMR (400 MHz, DMSO-d6) |? ppm 11.55 (s, 1H), 7.92 (d, J=1.87 Hz, 1H), 7.30 (dd, J=8.79, 1.89 Hz, 1H), 7.19 (d, J=8.78 Hz, 1H), 5.41 (s, 2H).

Properties of 5-BROMO-1H-INDAZOL-3-AMINE

Melting point:	171-175
Boiling point:	431.3±25.0 °C(Predicted)
Density	1.867±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
form	Liquid
pka	13?+-.0.40(Predicted)
color	Clear colorless
CAS DataBase Reference	61272-71-7

Safety information for 5-BROMO-1H-INDAZOL-3-AMINE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.