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HomeProduct name list5-Amino-2-chloropyridine

5-Amino-2-chloropyridine

  • CAS NO.:5350-93-6
  • Empirical Formula: C5H5ClN2
  • Molecular Weight: 128.56
  • MDL number: MFCD00006243
  • EINECS: 226-322-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
5-Amino-2-chloropyridine Structural

What is 5-Amino-2-chloropyridine?

Chemical properties

Light yellow to brown crystalline powder

The Uses of 5-Amino-2-chloropyridine

5-Amino-2-chloropyridine was used in the synthesis of [2H5]2-amino-l-methyl-6-phenylimidazo[4,5-b]pyridine. It was used in identification and evaluation of molecularly imprinted polymers for the selective removal of potentially genotoxic aminopyridine impurities from pharmaceuticals.

Definition

ChEBI: 3-Amino-6-chloropyridine is an aminopyridine.

General Description

5-Amino-2-chloropyridine undergoes Suzuki-Miyaura coupling with sterically hindered 2,6-dimethylphenylboronic acid. It undergoes facile temperature dependent displacement of chloride by bromide via Sandmeyer reaction to yield 2,5-dibromopyridine.

Properties of 5-Amino-2-chloropyridine

Melting point: 81-83 °C(lit.)
Boiling point: 205.39°C (rough estimate)
Density  1.2417 (rough estimate)
refractive index  1.5110 (estimate)
storage temp.  Keep in dark place,Inert atmosphere,Room temperature
form  powder to crystal
pka 1.94±0.10(Predicted)
color  White to Brown
BRN  108891
CAS DataBase Reference 5350-93-6(CAS DataBase Reference)

Safety information for 5-Amino-2-chloropyridine

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 5-Amino-2-chloropyridine

InChIKey QAJYCQZQLVENRZ-UHFFFAOYSA-N

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