4,4,4-TRIFLUORO-1-(2-FURYL)-1,3-BUTANEDIONE
- CAS NO.:326-90-9
- Empirical Formula: C8H5F3O3
- Molecular Weight: 206.12
- MDL number: MFCD00020935
- EINECS: 206-315-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is 4,4,4-TRIFLUORO-1-(2-FURYL)-1,3-BUTANEDIONE?
Chemical properties
clear yellow liquid
The Uses of 4,4,4-TRIFLUORO-1-(2-FURYL)-1,3-BUTANEDIONE
4,4,4-Trifluoro-1-(2-furyl)-1,3-butanedione (tfa) may be used in the following studies:
- As capping ligand in the synthesis of [Eu(tfa)3]2bpm complexes (bpm=2,2′-bipyrimidine).
- As reagent in the multistep synthesis of [13CD2]benzylamine.
- As reagent in the synthesis of 3-trifluoromethyl-2-arylcarbonylquinoxaline 1,4-di-N-oxide derivatives by reacting with corresponding benzofurazan oxides.
- In the efficient syntheses of perfluoroalkyl substituted azoles.
- Synthesis of 2-arylcarbonyl-3-trifluoromethylquinoxaline 1,4-di-N-oxide derivatives.
What are the applications of Application
4,4,4-Trifluoro-1-(2-furyl)-1,3-butanedione is employed in the efficient synthesis of perfluoroalkyl substituted azoles
General Description
4,4,4-Trifluoro-1-(2-furyl)-1,3-butanedione (furoyltrifluoroacetone, FTFA) is a β-diketone. Its cytotoxic activity against human cultured tumor and normal cells has been evaluated. Reports suggest that 4,4,4-trifluoro-1-(2-furyl)-1,3-butanedione partially inhibits the oxidation of ferrocyanide in ETP (electron transport particles) isolated from beef heart mitochondria. Its reaction with N,N,N′,N′-tetramethylalkyl diamines to form ionic adducts has been investigated. The conformational analysis of the enol and keto form of FTFA has been reported.
Properties of 4,4,4-TRIFLUORO-1-(2-FURYL)-1,3-BUTANEDIONE
Melting point: | 19-21 °C(lit.) |
Boiling point: | 203 °C(lit.) |
Density | 1.391 g/mL at 25 °C(lit.) |
refractive index | n |
Flash point: | 189 °F |
storage temp. | 2-8°C |
form | powder to lump to clear liquid |
pka | 5.56±0.23(Predicted) |
color | White or Colorless to Yellow to Orange |
FreezingPoint | 20.0 to 22.0 ℃ |
BRN | 168085 |
CAS DataBase Reference | 326-90-9(CAS DataBase Reference) |
EPA Substance Registry System | 1,3-Butanedione, 4,4,4-trifluoro-1-(2-furanyl)- (326-90-9) |
Safety information for 4,4,4-TRIFLUORO-1-(2-FURYL)-1,3-BUTANEDIONE
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H227:Flammable liquids H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for 4,4,4-TRIFLUORO-1-(2-FURYL)-1,3-BUTANEDIONE
InChIKey | OWLPCALGCHDBCN-UHFFFAOYSA-N |
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SYNOVA CHEMICALS
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Tubulysin A Tubulysin I Tubulysin F Tubulysin G Tubulysin M 3-FLUOROPYRROLIDINE HYDROCHLORIDE 4-CYANO-TETRAHYDROPYRAN-4-CARBOXYLIC ACID tetrahydro-4-methyl-2H-pyran 2,2-Difluoropropanol 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE 2,2-Difluoropropylamine hydrochloride 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Fuel shell 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Calcium Sodium Phosphosilicate IH 7-chloro-1- (2-methyl-4- nitrobenzoyl)-3,4- dihydro-1H-benzo[b] azepin-5(2H)-one 4-(2-fluoro-4- nitrophenyl) thiomorpholine Latanoprostene Bunod Lubiprostone Magnesium Trisilicate Flame Retardant Zinc Borate 1H-Imidazole-4-carbonitrileRelated products of tetrahydrofuran
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